Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985655466> ?p ?o ?g. }
- W1985655466 endingPage "152" @default.
- W1985655466 startingPage "147" @default.
- W1985655466 abstract "Injured spinal cord axons fail to regenerate in part due to a lack of trophic support. While various methods for replacing neurotrophins have been pursued, clinical uses of these methods face significant barriers. FK1706, a non-immunosuppressant neurophilin ligand, potentiates nerve growth factor signaling, suggesting therapeutic potential for functional deficits following spinal cord injury. Here, we demonstrate that FK1706 significantly improves behavioral outcomes in animal models of spinal cord hemisection and contusion injuries in rats. Furthermore, we show that FK1706 is effective even if administration is delayed until 1 week after injury, suggesting that FK1706 has a reasonable therapeutic time-window. Morphological analysis of injured axons in the dorsal corticospinal tract showed an increase in the radius and perimeter of stained axons, which were reduced by FK1706 treatment, suggesting that axonal swelling and retraction balls observed in injured spinal cord were improved by the neurotrophic effect of FK1706. Taken together, FK1706 improves both behavioral motor function and the underlying morphological changes, suggesting that FK1706 may have therapeutic potential in meeting the significant unmet needs in spinal cord injury." @default.
- W1985655466 created "2016-06-24" @default.
- W1985655466 creator A5013815950 @default.
- W1985655466 creator A5016629604 @default.
- W1985655466 creator A5023342096 @default.
- W1985655466 creator A5049025559 @default.
- W1985655466 creator A5076947182 @default.
- W1985655466 creator A5087620435 @default.
- W1985655466 date "2008-09-01" @default.
- W1985655466 modified "2023-10-14" @default.
- W1985655466 title "FK1706, a novel non-immunosuppressant neurophilin ligand, ameliorates motor dysfunction following spinal cord injury through its neuroregenerative action" @default.
- W1985655466 cites W1528188879 @default.
- W1985655466 cites W1651777585 @default.
- W1985655466 cites W1947829569 @default.
- W1985655466 cites W1963903234 @default.
- W1985655466 cites W1982068665 @default.
- W1985655466 cites W1997360763 @default.
- W1985655466 cites W1998651522 @default.
- W1985655466 cites W2001216342 @default.
- W1985655466 cites W2003687276 @default.
- W1985655466 cites W2012374665 @default.
- W1985655466 cites W2012428190 @default.
- W1985655466 cites W2012928251 @default.
- W1985655466 cites W2014203854 @default.
- W1985655466 cites W2014804210 @default.
- W1985655466 cites W2015808932 @default.
- W1985655466 cites W2017189850 @default.
- W1985655466 cites W2035493973 @default.
- W1985655466 cites W2038311122 @default.
- W1985655466 cites W2044900347 @default.
- W1985655466 cites W2047317904 @default.
- W1985655466 cites W2049832167 @default.
- W1985655466 cites W2052027207 @default.
- W1985655466 cites W2054934521 @default.
- W1985655466 cites W2075892765 @default.
- W1985655466 cites W2079186233 @default.
- W1985655466 cites W2080432557 @default.
- W1985655466 cites W2082619657 @default.
- W1985655466 cites W2084032294 @default.
- W1985655466 cites W2084088703 @default.
- W1985655466 cites W2089419444 @default.
- W1985655466 cites W2104907082 @default.
- W1985655466 cites W2111969459 @default.
- W1985655466 cites W2113100908 @default.
- W1985655466 cites W2124908609 @default.
- W1985655466 cites W2125691088 @default.
- W1985655466 cites W2126706634 @default.
- W1985655466 cites W2139272705 @default.
- W1985655466 cites W2140969998 @default.
- W1985655466 cites W2423484061 @default.
- W1985655466 cites W2976216518 @default.
- W1985655466 cites W4242872975 @default.
- W1985655466 doi "https://doi.org/10.1016/j.ejphar.2008.06.064" @default.
- W1985655466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18602914" @default.
- W1985655466 hasPublicationYear "2008" @default.
- W1985655466 type Work @default.
- W1985655466 sameAs 1985655466 @default.
- W1985655466 citedByCount "17" @default.
- W1985655466 countsByYear W19856554662012 @default.
- W1985655466 countsByYear W19856554662014 @default.
- W1985655466 countsByYear W19856554662015 @default.
- W1985655466 countsByYear W19856554662016 @default.
- W1985655466 countsByYear W19856554662017 @default.
- W1985655466 countsByYear W19856554662019 @default.
- W1985655466 countsByYear W19856554662021 @default.
- W1985655466 countsByYear W19856554662023 @default.
- W1985655466 crossrefType "journal-article" @default.
- W1985655466 hasAuthorship W1985655466A5013815950 @default.
- W1985655466 hasAuthorship W1985655466A5016629604 @default.
- W1985655466 hasAuthorship W1985655466A5023342096 @default.
- W1985655466 hasAuthorship W1985655466A5049025559 @default.
- W1985655466 hasAuthorship W1985655466A5076947182 @default.
- W1985655466 hasAuthorship W1985655466A5087620435 @default.
- W1985655466 hasConcept C118552586 @default.
- W1985655466 hasConcept C126322002 @default.
- W1985655466 hasConcept C126838900 @default.
- W1985655466 hasConcept C143409427 @default.
- W1985655466 hasConcept C149550507 @default.
- W1985655466 hasConcept C160539049 @default.
- W1985655466 hasConcept C169760540 @default.
- W1985655466 hasConcept C170493617 @default.
- W1985655466 hasConcept C2778334475 @default.
- W1985655466 hasConcept C2779779279 @default.
- W1985655466 hasConcept C2780775167 @default.
- W1985655466 hasConcept C42219234 @default.
- W1985655466 hasConcept C71924100 @default.
- W1985655466 hasConcept C86803240 @default.
- W1985655466 hasConceptScore W1985655466C118552586 @default.
- W1985655466 hasConceptScore W1985655466C126322002 @default.
- W1985655466 hasConceptScore W1985655466C126838900 @default.
- W1985655466 hasConceptScore W1985655466C143409427 @default.
- W1985655466 hasConceptScore W1985655466C149550507 @default.
- W1985655466 hasConceptScore W1985655466C160539049 @default.
- W1985655466 hasConceptScore W1985655466C169760540 @default.
- W1985655466 hasConceptScore W1985655466C170493617 @default.
- W1985655466 hasConceptScore W1985655466C2778334475 @default.
- W1985655466 hasConceptScore W1985655466C2779779279 @default.
- W1985655466 hasConceptScore W1985655466C2780775167 @default.