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- W1985655689 abstract "We studied both in vivo and in vitro specific host defense mechanisms in patients suffering from chronic post-traumatic osteomyelitis (n — 26). The cell-mediated immunity in vivo was impaired as indicated by the reduced reactivity in the delayed type hypersensitivity skin test. The concanavalin A or phytohemagglutinin-induced T-cell proliferation in vitro was markedly decreased in comparison to healthy donors. In contrast, B-cell proliferation stimulated by Staphylococcus aureus Cowan I was not altered. While the absolute lymphocyte counts and the percentage of T, B, and 0 cells were within the normal range, nine out of the 26 patients showed a significantly diminished ratio of CD4+ and CD8+ T cells. Humoral immunity in the patients was less affected as assessed by the unchanged serum levels of immunoglobulins (Ig). However, the T-cell dependent polyclonal Ig synthesis after in vitro stimulation with pokeweed mitogen was suppressed. Our results provide evidence that cell-mediated immune functions are predominantly impaired in patients with post-traumatic osteomyelitis which may contribute to the persistence of the localized bone infection." @default.
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- W1985655689 date "1991-01-01" @default.
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- W1985655689 title "Impairment of Specific Host Defense Mechanisms in Patients with Chronic Post-traumatic Osteomyelitis" @default.
- W1985655689 doi "https://doi.org/10.1097/00005373-199101000-00013" @default.
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