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- W1985663426 abstract "Neurofílament accumulation was produced in neuronal perikarya of the lower brain stem nuclei in the hamster brain by inoculating buffy coat from a patient with Alzheimer’s disease. The abnormally proliferated neurofílament was characterized by immuno-staining and electron microscopy. The intracytoplasmic neurofílament accumulation was positively stained with anti-tau and anti-ubiquitin, but not with antibody against paired helical filaments. Experimental neurofibrillary changes were produced in the rabbit brain by aluminum injection, and the proliferated neurofilaments in the rabbit brain were compared with those in the hamster brain inoculated with Alzheimer buffy coat. The results indicate that the long pathological process in the hamster brain is triggered by Alzheimers buffy coat inoculation which results in intracytoplasmic accumulation of modified neurofilaments." @default.
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- W1985663426 date "1991-01-01" @default.
- W1985663426 modified "2023-09-23" @default.
- W1985663426 title "Characterization of Intracytoplasmic Neurofilament Accumulation in Hamster Brain Caused by Alzheimer Buffy Coat Inoculation: Comparison with Experimental Neurofibrillary Changes Produced by Aluminum Intoxication" @default.
- W1985663426 doi "https://doi.org/10.1159/000213295" @default.
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