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• W1985671448 endingPage "11734" @default.
• W1985671448 startingPage "11729" @default.
• W1985671448 abstract "Of the DNA bases, peroxynitrite (ONOO-) is most reactive toward 2'-deoxyguanosine (dGuo), but even more reactive with 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodGuo), requiring a 1,000-fold excess of dGuo to provide 50% protection against the reaction with 8-oxodGuo. Therefore, it seems reasonable that 8-oxodGuo is a potentially important target in DNA and that the structures of the reaction products with ONOO- should be characterized. Using 3', 5'-di-O-Ac-8-oxodGuo as a model compound, the reaction products with ONOO- have been isolated and identified under simulated physiological reaction conditions (phosphate/bicarbonate buffer at pH 7.2). The major reaction product, II, is unstable and undergoes base-mediated hydrolysis to 2,5-diaminoimidazol-4-one, IIa, and 3-(3, 5-di-O-Ac-2-deoxy-beta-D-erythro-pentofuranosyl)-5-iminoimidazolidine -2,4-dione, IIb. The latter compound further hydrolyzes to 3-(3, 5-di-O-Ac-2-deoxy-beta-D-erythro-pentofuranosyl)oxaluric acid, IIc. Other products include 3-(3, 5-di-O-Ac-2-deoxy-beta-D-erythro-pentofuranosyl)-2,4,6-trioxo-[1,3, 5]triazinane-1-carboxamidine, I, which further hydrolyzes to 1-(3, 5-di-O-Ac-2-deoxy-beta-D-erythro-pentofuranosyl)cyanuric acid, Ia. 1-(3,5-di-O-Ac-2-deoxy-beta-D-erythro-pentofuranosyl)parabanic acid, III, is a minor product that also may contribute to formation of IIc. The major products formed in these reactions are biologically uncharacterized but are similar to modified DNA bases that have been shown to be both premutagenic and blocks to DNA polymerization." @default.
• W1985671448 created "2016-06-24" @default.
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• W1985671448 date "1999-10-12" @default.
• W1985671448 modified "2023-10-16" @default.
• W1985671448 title "Peroxynitrite reaction products of 3′,5′-di <i>-O-</i> acetyl-8-oxo-7,8-dihydro-2′-deoxyguanosine" @default.
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• W1985671448 doi "https://doi.org/10.1073/pnas.96.21.11729" @default.
• W1985671448 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/18354" @default.
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