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• W1985677046 abstract "Mitochondrial Ca2+ is known to change dynamically, regulating mitochondrial as well as cellular functions such as energy metabolism and apoptosis. The NCLX gene encodes the mitochondrial Na+-Ca2+ exchanger (NCXmit), a Ca2+ extrusion system in mitochondria. Here we report that the NCLX regulates automaticity of the HL-1 cardiomyocytes. NCLX knockdown using siRNA resulted in the marked prolongation of the cycle length of spontaneous Ca2+ oscillation and action potential generation. The upstrokes of action potential and Ca2+ transient were markedly slower and sarcoplasmic reticulum (SR) Ca2+ handling were compromised in the NCLX knockdown cells. Analyses using a mathematical model of HL-1 cardiomyocytes demonstrated that blocking NCXmit reduced the SR Ca2+ content to slow spontaneous SR Ca2+ leak, which is a trigger of automaticity. We propose that NCLX is a novel molecule to regulate automaticity of cardiomyocytes via modulating SR Ca2+ handling." @default.
• W1985677046 created "2016-06-24" @default.
• W1985677046 creator A5002746408 @default.
• W1985677046 creator A5011910796 @default.
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• W1985677046 date "2013-09-26" @default.
• W1985677046 modified "2023-09-25" @default.
• W1985677046 title "The mitochondrial Na+-Ca2+ exchanger, NCLX, regulates automaticity of HL-1 cardiomyocytes" @default.
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• W1985677046 doi "https://doi.org/10.1038/srep02766" @default.
• W1985677046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3783885" @default.
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