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- W1985677612 abstract "Nuclear factor of activated T cells (NFAT) is a critical regulator of early gene transcription in response to TCR-mediated signals. Here, we show that mice lacking both NFATp and NFAT4 develop a profound lymphoproliferative disorder likely due to a lowered threshold for TCR signaling coupled with increased resistance to apoptosis secondary to defective FasL expression. NFAT mutant mice also have allergic blepharitis, interstitial pneumonitis, and a 103 to 104 fold increase in serum IgG1 and IgE levels, secondary to a dramatic and selective increase in Th2 cytokines. This phenotype may be ascribed to unopposed occupancy of the IL-4 promoter by NFATc. Our data demonstrate that lymphoid homeostasis and Th2 activation require a critical balance among NFAT family members." @default.
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- W1985677612 date "1998-11-01" @default.
- W1985677612 modified "2023-10-11" @default.
- W1985677612 title "Inhibitory Function of Two NFAT Family Members in Lymphoid Homeostasis and Th2 Development" @default.
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- W1985677612 doi "https://doi.org/10.1016/s1074-7613(00)80660-3" @default.
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