FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985679571> ?p ?o ?g. }

• W1985679571 endingPage "852" @default.
• W1985679571 startingPage "848" @default.
• W1985679571 abstract "BackgroundAlthough surgical resection remains the mainstay of treatment for metastatic pulmonary colorectal cancer, 5-year survival approaches only 30% to 40%. We have developed a model of isolated left lung perfusion (ILP) with FUDR (2′-deoxy-5-fluorouridine) for the treatment of pulmonary colorectal metastases. FUDR ILP toxicity and pharmacokinetics were evaluated and compared with continuous intravenous infusion in the rat.MethodsToxicity was first evaluated in F344 rats (n = 17) after left ILP (20-minute perfusion at 0.5 mL/min) with 21 mg/mL (n = 11), 28 mg/mL (n = 2), 35 mg/mL (n = 2), and 70 mg/mL (n = 2) of FUDR. Animals were followed up and weights recorded for 14 days postoperatively before a right pneumonectomy was performed to evaluate the effect of FUDR perfusion on left lung function. In the second study, 32 rats (n = 8/group) underwent: systemic FUDR (intravenous), or ILP with 7, 14, and 21 mg/mL respectively (ILP 7, ILP 14, and ILP 21 groups). Left lungs and serum were analyzed for FUDR and 5-fluorouracil by high-performance liquid chromatography.ResultsRats perfused with doses of FUDR greater than 21 mg/mL died perioperatively. All animals perfused at 21 mg/mL survived until day 14, and 8/11 survived a right pneumonectomy. Rats that survived ILP resumed normal weight gain and grooming habits within 1 week. Pharmacokinetic evaluation demonstrated that ILP at 21 mg/mL maximally elevated total lung FUDR and 5-fluorouracil levels (508.5 ± 96.4 μg/g lung) in comparison with the ILP 14, ILP 7, and intravenous groups (299.1 ± 44.8,116.0 ± 21.1, and 7.5 ± 4.1 μg/g lung, respectively) (p < 0.05). Serum FUDR levels were 10.5 ± 6.8,1.3 ± 0.5, 2.31 ± 1.1, and 1.2 ± 0.4 μg/g lung (p = not significant) for intravenous, ILP 7, ILP 14, and ILP 21 groups, respectively.ConclusionsIsolated left lung perfusion with FUDR is well tolerated to a maximum dose of 21 mg/mL and results in significantly higher FUDR and 5-fluorouracil lung levels with low serum levels compared with intravenous treatment. These higher pulmonary levels may offer advantages in the treatment of pulmonary colorectal metastases. Although surgical resection remains the mainstay of treatment for metastatic pulmonary colorectal cancer, 5-year survival approaches only 30% to 40%. We have developed a model of isolated left lung perfusion (ILP) with FUDR (2′-deoxy-5-fluorouridine) for the treatment of pulmonary colorectal metastases. FUDR ILP toxicity and pharmacokinetics were evaluated and compared with continuous intravenous infusion in the rat. Toxicity was first evaluated in F344 rats (n = 17) after left ILP (20-minute perfusion at 0.5 mL/min) with 21 mg/mL (n = 11), 28 mg/mL (n = 2), 35 mg/mL (n = 2), and 70 mg/mL (n = 2) of FUDR. Animals were followed up and weights recorded for 14 days postoperatively before a right pneumonectomy was performed to evaluate the effect of FUDR perfusion on left lung function. In the second study, 32 rats (n = 8/group) underwent: systemic FUDR (intravenous), or ILP with 7, 14, and 21 mg/mL respectively (ILP 7, ILP 14, and ILP 21 groups). Left lungs and serum were analyzed for FUDR and 5-fluorouracil by high-performance liquid chromatography. Rats perfused with doses of FUDR greater than 21 mg/mL died perioperatively. All animals perfused at 21 mg/mL survived until day 14, and 8/11 survived a right pneumonectomy. Rats that survived ILP resumed normal weight gain and grooming habits within 1 week. Pharmacokinetic evaluation demonstrated that ILP at 21 mg/mL maximally elevated total lung FUDR and 5-fluorouracil levels (508.5 ± 96.4 μg/g lung) in comparison with the ILP 14, ILP 7, and intravenous groups (299.1 ± 44.8,116.0 ± 21.1, and 7.5 ± 4.1 μg/g lung, respectively) (p < 0.05). Serum FUDR levels were 10.5 ± 6.8,1.3 ± 0.5, 2.31 ± 1.1, and 1.2 ± 0.4 μg/g lung (p = not significant) for intravenous, ILP 7, ILP 14, and ILP 21 groups, respectively. Isolated left lung perfusion with FUDR is well tolerated to a maximum dose of 21 mg/mL and results in significantly higher FUDR and 5-fluorouracil lung levels with low serum levels compared with intravenous treatment. These higher pulmonary levels may offer advantages in the treatment of pulmonary colorectal metastases." @default.
• W1985679571 created "2016-06-24" @default.
• W1985679571 creator A5015014900 @default.
• W1985679571 creator A5020614443 @default.
• W1985679571 creator A5053267529 @default.
• W1985679571 creator A5060071245 @default.
• W1985679571 creator A5060394398 @default.
• W1985679571 creator A5080828667 @default.
• W1985679571 date "1996-08-01" @default.
• W1985679571 modified "2023-09-26" @default.
• W1985679571 title "Isolated Lung Perfusion With FUDR in the Rat: Pharmacokinetics and Survival" @default.
• W1985679571 cites W1964339941 @default.
• W1985679571 cites W1972465013 @default.
• W1985679571 cites W1984744992 @default.
• W1985679571 cites W1986924507 @default.
• W1985679571 cites W1988036554 @default.
• W1985679571 cites W2011762965 @default.
• W1985679571 cites W2024260681 @default.
• W1985679571 cites W2047510518 @default.
• W1985679571 cites W2056136074 @default.
• W1985679571 cites W2075559527 @default.
• W1985679571 cites W2082662440 @default.
• W1985679571 cites W2229046373 @default.
• W1985679571 cites W2344981287 @default.
• W1985679571 cites W4301497321 @default.
• W1985679571 doi "https://doi.org/10.1016/s0003-4975(96)00508-5" @default.
• W1985679571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8784018" @default.
• W1985679571 hasPublicationYear "1996" @default.
• W1985679571 type Work @default.
• W1985679571 sameAs 1985679571 @default.
• W1985679571 citedByCount "9" @default.
• W1985679571 countsByYear W19856795712016 @default.
• W1985679571 crossrefType "journal-article" @default.
• W1985679571 hasAuthorship W1985679571A5015014900 @default.
• W1985679571 hasAuthorship W1985679571A5020614443 @default.
• W1985679571 hasAuthorship W1985679571A5053267529 @default.
• W1985679571 hasAuthorship W1985679571A5060071245 @default.
• W1985679571 hasAuthorship W1985679571A5060394398 @default.
• W1985679571 hasAuthorship W1985679571A5080828667 @default.
• W1985679571 hasBestOaLocation W19856795711 @default.
• W1985679571 hasConcept C112705442 @default.
• W1985679571 hasConcept C121608353 @default.
• W1985679571 hasConcept C126322002 @default.
• W1985679571 hasConcept C126894567 @default.
• W1985679571 hasConcept C141071460 @default.
• W1985679571 hasConcept C146957229 @default.
• W1985679571 hasConcept C2776256026 @default.
• W1985679571 hasConcept C2776694085 @default.
• W1985679571 hasConcept C2777589429 @default.
• W1985679571 hasConcept C2777714996 @default.
• W1985679571 hasConcept C2780456651 @default.
• W1985679571 hasConcept C42219234 @default.
• W1985679571 hasConcept C526805850 @default.
• W1985679571 hasConcept C71924100 @default.
• W1985679571 hasConcept C90924648 @default.
• W1985679571 hasConcept C98274493 @default.
• W1985679571 hasConceptScore W1985679571C112705442 @default.
• W1985679571 hasConceptScore W1985679571C121608353 @default.
• W1985679571 hasConceptScore W1985679571C126322002 @default.
• W1985679571 hasConceptScore W1985679571C126894567 @default.
• W1985679571 hasConceptScore W1985679571C141071460 @default.
• W1985679571 hasConceptScore W1985679571C146957229 @default.
• W1985679571 hasConceptScore W1985679571C2776256026 @default.
• W1985679571 hasConceptScore W1985679571C2776694085 @default.
• W1985679571 hasConceptScore W1985679571C2777589429 @default.
• W1985679571 hasConceptScore W1985679571C2777714996 @default.
• W1985679571 hasConceptScore W1985679571C2780456651 @default.
• W1985679571 hasConceptScore W1985679571C42219234 @default.
• W1985679571 hasConceptScore W1985679571C526805850 @default.
• W1985679571 hasConceptScore W1985679571C71924100 @default.
• W1985679571 hasConceptScore W1985679571C90924648 @default.
• W1985679571 hasConceptScore W1985679571C98274493 @default.
• W1985679571 hasIssue "3" @default.
• W1985679571 hasLocation W19856795711 @default.
• W1985679571 hasLocation W19856795712 @default.
• W1985679571 hasOpenAccess W1985679571 @default.
• W1985679571 hasPrimaryLocation W19856795711 @default.
• W1985679571 hasRelatedWork W1590282786 @default.
• W1985679571 hasRelatedWork W2066883220 @default.
• W1985679571 hasRelatedWork W2071418871 @default.
• W1985679571 hasRelatedWork W2189014522 @default.
• W1985679571 hasRelatedWork W2255943830 @default.
• W1985679571 hasRelatedWork W2344981287 @default.
• W1985679571 hasRelatedWork W2374285734 @default.
• W1985679571 hasRelatedWork W2380382254 @default.
• W1985679571 hasRelatedWork W2412727163 @default.
• W1985679571 hasRelatedWork W3030265619 @default.
• W1985679571 hasVolume "62" @default.
• W1985679571 isParatext "false" @default.
• W1985679571 isRetracted "false" @default.
• W1985679571 magId "1985679571" @default.
• W1985679571 workType "article" @default.