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- W1985680333 abstract "Sickle cell trait (SCT) is unique among the carrier states that are identified during newborn screening. Unlike other heterozygous states for rare recessive diseases, SCT is exceedingly prevalent throughout regions of the world, making sickle cell disease one of the most common monogenetic diseases worldwide. Because of this high frequency, reproductive counseling is of paramount importance. In addition, unlike other carrier states, SCT seems to be a risk factor for several clinical complications, such as extreme exertional injury, chronic kidney disease, and venous thromboembolism. Increasing knowledge about these clinical outcomes can help inform genetic counseling recommendations. Expanding research and clinical efforts are needed to ensure that the promises of modern and precision medicine can be delivered to the millions of SCT carriers and their children." @default.
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- W1985680333 date "1987-01-01" @default.
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- W1985680333 title "The pathophysiology of HIV infection: A complex pathway of host-virus interaction" @default.
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- W1985680333 doi "https://doi.org/10.1016/s0769-2617(87)80070-9" @default.
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