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- W1985681707 abstract "1. The effects of hyperosmotic NaCl and sucrose solutions on the responsiveness to noradrena-line (NA) were studied in isolated rat right and left atria. 2. Sucrose caused subsensitivity to NA and isoprenaline in right atria, which was abolished by atropine. 3. NaCl caused subsensitivity only to NA in both atria, which was reversed by imipramine. 4. Both solutions decreased the maximum tension of left atria after maximal NA and Ca2+ concentrations. 5. The results suggest that hyperosmolality reduces the atrial responsiveness to NA by directly depressing contractility and increasing acetylcholine release. However, if the solute is NaCl, the main mechanism seems to be an increase of the catecholamine neuronal uptake." @default.
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- W1985681707 date "1991-01-01" @default.
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- W1985681707 title "Reduced responsiveness to noradrenaline in isolated rat atria exposed to hyperosmotic solutions" @default.
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- W1985681707 doi "https://doi.org/10.1016/0306-3623(91)90326-2" @default.
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