FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985683101> ?p ?o ?g. }

• W1985683101 endingPage "791" @default.
• W1985683101 startingPage "779" @default.
• W1985683101 abstract "Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors controlling the expression of genes involved in lipid homeostasis. PPARs activate gene transcription in response to a variety of compounds including hypolipidemic drugs as well as natural fatty acids. From the plethora of PPAR activators, Scatchard analysis of receptor-ligand interactions has thus far identified only four ligands. These are the chemotactic agent leukotriene B4 and the hypolipidemic drug Wy 14,643 for the alpha-subtype and a prostaglandin J2 metabolite and synthetic antidiabetic thiazolidinediones for the gamma-subtype. Based on the hypothesis that ligand binding to PPAR would induce interactions of the receptor with transcriptional coactivators, we have developed a novel ligand sensor assay, termed coactivator-dependent receptor ligand assay (CARLA). With CARLA we have screened several natural and synthetic candidate ligands and have identified naturally occurring fatty acids and metabolites as well as hypolipidemic drugs as bona fide ligands of the three PPAR subtypes from Xenopus laevis. Our results suggest that PPARs, by their ability to interact with a number of structurally diverse compounds, have acquired unique ligand-binding properties among the superfamily of nuclear receptors that are compatible with their biological activity." @default.
• W1985683101 created "2016-06-24" @default.
• W1985683101 creator A5028706835 @default.
• W1985683101 creator A5037086101 @default.
• W1985683101 creator A5040542231 @default.
• W1985683101 creator A5044800793 @default.
• W1985683101 creator A5045561158 @default.
• W1985683101 creator A5052583137 @default.
• W1985683101 creator A5083722213 @default.
• W1985683101 date "1997-06-01" @default.
• W1985683101 modified "2023-10-10" @default.
• W1985683101 title "Fatty Acids, Eicosanoids, and Hypolipidemic Agents Identified as Ligands of Peroxisome Proliferator-Activated Receptors by Coactivator-Dependent Receptor Ligand Assay" @default.
• W1985683101 cites W1493268813 @default.
• W1985683101 cites W1541759393 @default.
• W1985683101 cites W1547032503 @default.
• W1985683101 cites W1562107474 @default.
• W1985683101 cites W1602722523 @default.
• W1985683101 cites W1671834350 @default.
• W1985683101 cites W1969567327 @default.
• W1985683101 cites W1970312964 @default.
• W1985683101 cites W1975733077 @default.
• W1985683101 cites W1978125779 @default.
• W1985683101 cites W1990120674 @default.
• W1985683101 cites W1994212260 @default.
• W1985683101 cites W1997403350 @default.
• W1985683101 cites W2005674716 @default.
• W1985683101 cites W2016298359 @default.
• W1985683101 cites W2047591801 @default.
• W1985683101 cites W2047982128 @default.
• W1985683101 cites W2050717908 @default.
• W1985683101 cites W2066092624 @default.
• W1985683101 cites W2068113812 @default.
• W1985683101 cites W2068669347 @default.
• W1985683101 cites W2072881510 @default.
• W1985683101 cites W2086376157 @default.
• W1985683101 cites W2107752044 @default.
• W1985683101 cites W2114437978 @default.
• W1985683101 cites W2116470680 @default.
• W1985683101 cites W2143241514 @default.
• W1985683101 cites W2150557496 @default.
• W1985683101 cites W2159270178 @default.
• W1985683101 cites W2160402926 @default.
• W1985683101 cites W2229507033 @default.
• W1985683101 cites W2335922553 @default.
• W1985683101 doi "https://doi.org/10.1210/mend.11.6.0007" @default.
• W1985683101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9171241" @default.
• W1985683101 hasPublicationYear "1997" @default.
• W1985683101 type Work @default.
• W1985683101 sameAs 1985683101 @default.
• W1985683101 citedByCount "915" @default.
• W1985683101 countsByYear W19856831012012 @default.
• W1985683101 countsByYear W19856831012013 @default.
• W1985683101 countsByYear W19856831012014 @default.
• W1985683101 countsByYear W19856831012015 @default.
• W1985683101 countsByYear W19856831012016 @default.
• W1985683101 countsByYear W19856831012017 @default.
• W1985683101 countsByYear W19856831012018 @default.
• W1985683101 countsByYear W19856831012019 @default.
• W1985683101 countsByYear W19856831012020 @default.
• W1985683101 countsByYear W19856831012021 @default.
• W1985683101 countsByYear W19856831012022 @default.
• W1985683101 countsByYear W19856831012023 @default.
• W1985683101 crossrefType "journal-article" @default.
• W1985683101 hasAuthorship W1985683101A5028706835 @default.
• W1985683101 hasAuthorship W1985683101A5037086101 @default.
• W1985683101 hasAuthorship W1985683101A5040542231 @default.
• W1985683101 hasAuthorship W1985683101A5044800793 @default.
• W1985683101 hasAuthorship W1985683101A5045561158 @default.
• W1985683101 hasAuthorship W1985683101A5052583137 @default.
• W1985683101 hasAuthorship W1985683101A5083722213 @default.
• W1985683101 hasBestOaLocation W19856831011 @default.
• W1985683101 hasConcept C104317684 @default.
• W1985683101 hasConcept C116569031 @default.
• W1985683101 hasConcept C127078168 @default.
• W1985683101 hasConcept C14093617 @default.
• W1985683101 hasConcept C170493617 @default.
• W1985683101 hasConcept C187345961 @default.
• W1985683101 hasConcept C188413054 @default.
• W1985683101 hasConcept C55493867 @default.
• W1985683101 hasConcept C63932345 @default.
• W1985683101 hasConcept C77445288 @default.
• W1985683101 hasConcept C86339819 @default.
• W1985683101 hasConcept C86803240 @default.
• W1985683101 hasConceptScore W1985683101C104317684 @default.
• W1985683101 hasConceptScore W1985683101C116569031 @default.
• W1985683101 hasConceptScore W1985683101C127078168 @default.
• W1985683101 hasConceptScore W1985683101C14093617 @default.
• W1985683101 hasConceptScore W1985683101C170493617 @default.
• W1985683101 hasConceptScore W1985683101C187345961 @default.
• W1985683101 hasConceptScore W1985683101C188413054 @default.
• W1985683101 hasConceptScore W1985683101C55493867 @default.
• W1985683101 hasConceptScore W1985683101C63932345 @default.
• W1985683101 hasConceptScore W1985683101C77445288 @default.
• W1985683101 hasConceptScore W1985683101C86339819 @default.
• W1985683101 hasConceptScore W1985683101C86803240 @default.
• W1985683101 hasIssue "6" @default.
• W1985683101 hasLocation W19856831011 @default.
• W1985683101 hasLocation W19856831012 @default.

• next