Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985684295> ?p ?o ?g. }
- W1985684295 endingPage "1234" @default.
- W1985684295 startingPage "1223" @default.
- W1985684295 abstract "BACKGROUND Fibroblast growth factor 8 (FGF8) is over-expressed in prostate cancer (CaP) correlating with high-grade disease and reduced survival. The role of acetylation in transcriptional regulation of FGF8 was investigated using the histone deacetylase (HDAC) inhibitor Trichostatin A (TSA). METHODS FGF8 transcriptional response to TSA was investigated by gene reporter assays, RT-PCR, and Western blotting. Chromatin immunoprecipitation (ChIP) assays were also performed. RESULTS FGF8 is upregulated in response to TSA treatment along with NF-κB transcriptional activity. Over-expression of p65 activated FGF8 transcription. ChIP assays revealed p65 recruitment to the fgf8 promoter, containing putative NF-κB binding sites, post TSA stimulation. PI-3K activity is required for TSA mediated FGF8 upregulation. CONCLUSION Using TSA treatment in prostate cancer cells, a requirement of PI-3K activity in mediating TSA function is demonstrated and a novel role for NF-κB in the regulation of FGF8 expression is uncovered. Prostate © 2006 Wiley-Liss, Inc." @default.
- W1985684295 created "2016-06-24" @default.
- W1985684295 creator A5020424520 @default.
- W1985684295 creator A5056678600 @default.
- W1985684295 creator A5062478414 @default.
- W1985684295 date "2006-01-01" @default.
- W1985684295 modified "2023-09-26" @default.
- W1985684295 title "NF-κB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells" @default.
- W1985684295 cites W1534895763 @default.
- W1985684295 cites W1807380980 @default.
- W1985684295 cites W1976712056 @default.
- W1985684295 cites W1978664410 @default.
- W1985684295 cites W1980223730 @default.
- W1985684295 cites W1980870391 @default.
- W1985684295 cites W1981591956 @default.
- W1985684295 cites W1985177598 @default.
- W1985684295 cites W1988784224 @default.
- W1985684295 cites W1991995900 @default.
- W1985684295 cites W1999309742 @default.
- W1985684295 cites W2002574363 @default.
- W1985684295 cites W2008836678 @default.
- W1985684295 cites W2013165053 @default.
- W1985684295 cites W2014269608 @default.
- W1985684295 cites W2017549518 @default.
- W1985684295 cites W2022839567 @default.
- W1985684295 cites W2027929872 @default.
- W1985684295 cites W2031397616 @default.
- W1985684295 cites W2039203273 @default.
- W1985684295 cites W2050567539 @default.
- W1985684295 cites W2058112104 @default.
- W1985684295 cites W2065578770 @default.
- W1985684295 cites W2072259101 @default.
- W1985684295 cites W2076362571 @default.
- W1985684295 cites W2086889008 @default.
- W1985684295 cites W20888715 @default.
- W1985684295 cites W2090597801 @default.
- W1985684295 cites W2090906911 @default.
- W1985684295 cites W2096654508 @default.
- W1985684295 cites W2098194379 @default.
- W1985684295 cites W2099740899 @default.
- W1985684295 cites W2107558077 @default.
- W1985684295 cites W2111843532 @default.
- W1985684295 cites W2119218166 @default.
- W1985684295 cites W2123822150 @default.
- W1985684295 cites W2125751034 @default.
- W1985684295 cites W2144929276 @default.
- W1985684295 cites W2148119611 @default.
- W1985684295 cites W2155245588 @default.
- W1985684295 cites W2171865516 @default.
- W1985684295 cites W2314325548 @default.
- W1985684295 cites W2328982351 @default.
- W1985684295 doi "https://doi.org/10.1002/pros.20376" @default.
- W1985684295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16683270" @default.
- W1985684295 hasPublicationYear "2006" @default.
- W1985684295 type Work @default.
- W1985684295 sameAs 1985684295 @default.
- W1985684295 citedByCount "17" @default.
- W1985684295 countsByYear W19856842952012 @default.
- W1985684295 countsByYear W19856842952013 @default.
- W1985684295 countsByYear W19856842952015 @default.
- W1985684295 countsByYear W19856842952016 @default.
- W1985684295 countsByYear W19856842952018 @default.
- W1985684295 countsByYear W19856842952019 @default.
- W1985684295 countsByYear W19856842952020 @default.
- W1985684295 countsByYear W19856842952022 @default.
- W1985684295 countsByYear W19856842952023 @default.
- W1985684295 crossrefType "journal-article" @default.
- W1985684295 hasAuthorship W1985684295A5020424520 @default.
- W1985684295 hasAuthorship W1985684295A5056678600 @default.
- W1985684295 hasAuthorship W1985684295A5062478414 @default.
- W1985684295 hasConcept C101762097 @default.
- W1985684295 hasConcept C104317684 @default.
- W1985684295 hasConcept C121608353 @default.
- W1985684295 hasConcept C127561419 @default.
- W1985684295 hasConcept C134320426 @default.
- W1985684295 hasConcept C150194340 @default.
- W1985684295 hasConcept C153911025 @default.
- W1985684295 hasConcept C170493617 @default.
- W1985684295 hasConcept C2776094402 @default.
- W1985684295 hasConcept C2777865847 @default.
- W1985684295 hasConcept C2778305200 @default.
- W1985684295 hasConcept C2780192828 @default.
- W1985684295 hasConcept C502942594 @default.
- W1985684295 hasConcept C54355233 @default.
- W1985684295 hasConcept C64927066 @default.
- W1985684295 hasConcept C74373430 @default.
- W1985684295 hasConcept C86339819 @default.
- W1985684295 hasConcept C86803240 @default.
- W1985684295 hasConceptScore W1985684295C101762097 @default.
- W1985684295 hasConceptScore W1985684295C104317684 @default.
- W1985684295 hasConceptScore W1985684295C121608353 @default.
- W1985684295 hasConceptScore W1985684295C127561419 @default.
- W1985684295 hasConceptScore W1985684295C134320426 @default.
- W1985684295 hasConceptScore W1985684295C150194340 @default.
- W1985684295 hasConceptScore W1985684295C153911025 @default.
- W1985684295 hasConceptScore W1985684295C170493617 @default.
- W1985684295 hasConceptScore W1985684295C2776094402 @default.
- W1985684295 hasConceptScore W1985684295C2777865847 @default.