Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985692169> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1985692169 endingPage "293" @default.
- W1985692169 startingPage "289" @default.
- W1985692169 abstract "Mesothelial cell monolayers have been reported to prevent infiltration of cancer cells into the peritoneum. We have previously reported that peritoneal fibrosis induced by gastric cancer cells prior to metastatization may provide a congenial environment for peritoneal metastases. In this study, we investigated the effects of peritoneal fibroblasts on peritoneal mesothelial cell morphology. Human gastric cancer (OCUM-2MD3), peritoneal fibroblast (NF-2P) and mesothelial (MS-1) cell lines were established in our laboratory. Histology of the peritoneum was investigated following intraperitoneal inoculation of serum-free conditioned media (SF-CM) from OCUM-2MD3 cells into nude mice. SF-CM from peritoneal fibroblasts was added to monolayer-cultured mesothelial cells, and their morphology was examined by phase-contrast microscopy. This experiment was conducted in the presence and absence of neutralizing antibodies against various factors. Mesothelial cells exposed to fibroblasts proliferation became hemispherical and separated from each other, while unexposed mesothelium remained as a flat monolayer. Cultured-mesothelial cells rounded up or exhibited a fibroblast-like shape following the addition of peritoneal fibroblast SF-CM. Anti-hepatocyte growth factor (HGF) neutralizing antibody partly inhibited this effect. We suggest that soluble factors, such as HGF, produced by peritoneal fibroblasts affect the morphology of mesothelial cells in monolayers so that the resulting environment may become prone to the peritoneal dissemination of cancer cells." @default.
- W1985692169 created "2016-06-24" @default.
- W1985692169 creator A5007644928 @default.
- W1985692169 creator A5013369646 @default.
- W1985692169 creator A5018984030 @default.
- W1985692169 creator A5032709542 @default.
- W1985692169 creator A5041932199 @default.
- W1985692169 creator A5047939598 @default.
- W1985692169 creator A5089607790 @default.
- W1985692169 date "1996-07-17" @default.
- W1985692169 modified "2023-10-06" @default.
- W1985692169 title "Hepatocyte growth factor (HGF) produced by peritoneal fibroblasts may affect mesothelial cell morphology and promote peritoneal dissemination" @default.
- W1985692169 cites W1600831053 @default.
- W1985692169 cites W1964895324 @default.
- W1985692169 cites W1969109645 @default.
- W1985692169 cites W1985968411 @default.
- W1985692169 cites W1997836918 @default.
- W1985692169 cites W2002695314 @default.
- W1985692169 cites W2015759068 @default.
- W1985692169 cites W2027219031 @default.
- W1985692169 cites W2035265540 @default.
- W1985692169 cites W2037518112 @default.
- W1985692169 cites W2044895358 @default.
- W1985692169 cites W2044946668 @default.
- W1985692169 cites W4250710509 @default.
- W1985692169 doi "https://doi.org/10.1002/(sici)1097-0215(19960717)67:2<289::aid-ijc22>3.0.co;2-5" @default.
- W1985692169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8760601" @default.
- W1985692169 hasPublicationYear "1996" @default.
- W1985692169 type Work @default.
- W1985692169 sameAs 1985692169 @default.
- W1985692169 citedByCount "64" @default.
- W1985692169 countsByYear W19856921692012 @default.
- W1985692169 countsByYear W19856921692013 @default.
- W1985692169 countsByYear W19856921692014 @default.
- W1985692169 countsByYear W19856921692015 @default.
- W1985692169 countsByYear W19856921692016 @default.
- W1985692169 countsByYear W19856921692017 @default.
- W1985692169 countsByYear W19856921692020 @default.
- W1985692169 countsByYear W19856921692022 @default.
- W1985692169 crossrefType "journal-article" @default.
- W1985692169 hasAuthorship W1985692169A5007644928 @default.
- W1985692169 hasAuthorship W1985692169A5013369646 @default.
- W1985692169 hasAuthorship W1985692169A5018984030 @default.
- W1985692169 hasAuthorship W1985692169A5032709542 @default.
- W1985692169 hasAuthorship W1985692169A5041932199 @default.
- W1985692169 hasAuthorship W1985692169A5047939598 @default.
- W1985692169 hasAuthorship W1985692169A5089607790 @default.
- W1985692169 hasConcept C105702510 @default.
- W1985692169 hasConcept C126322002 @default.
- W1985692169 hasConcept C142724271 @default.
- W1985692169 hasConcept C170493617 @default.
- W1985692169 hasConcept C2776001837 @default.
- W1985692169 hasConcept C2776996007 @default.
- W1985692169 hasConcept C2778536324 @default.
- W1985692169 hasConcept C2779747549 @default.
- W1985692169 hasConcept C2780381497 @default.
- W1985692169 hasConcept C2909640154 @default.
- W1985692169 hasConcept C502942594 @default.
- W1985692169 hasConcept C54355233 @default.
- W1985692169 hasConcept C71924100 @default.
- W1985692169 hasConcept C81885089 @default.
- W1985692169 hasConcept C86803240 @default.
- W1985692169 hasConceptScore W1985692169C105702510 @default.
- W1985692169 hasConceptScore W1985692169C126322002 @default.
- W1985692169 hasConceptScore W1985692169C142724271 @default.
- W1985692169 hasConceptScore W1985692169C170493617 @default.
- W1985692169 hasConceptScore W1985692169C2776001837 @default.
- W1985692169 hasConceptScore W1985692169C2776996007 @default.
- W1985692169 hasConceptScore W1985692169C2778536324 @default.
- W1985692169 hasConceptScore W1985692169C2779747549 @default.
- W1985692169 hasConceptScore W1985692169C2780381497 @default.
- W1985692169 hasConceptScore W1985692169C2909640154 @default.
- W1985692169 hasConceptScore W1985692169C502942594 @default.
- W1985692169 hasConceptScore W1985692169C54355233 @default.
- W1985692169 hasConceptScore W1985692169C71924100 @default.
- W1985692169 hasConceptScore W1985692169C81885089 @default.
- W1985692169 hasConceptScore W1985692169C86803240 @default.
- W1985692169 hasIssue "2" @default.
- W1985692169 hasLocation W19856921691 @default.
- W1985692169 hasLocation W19856921692 @default.
- W1985692169 hasOpenAccess W1985692169 @default.
- W1985692169 hasPrimaryLocation W19856921691 @default.
- W1985692169 hasRelatedWork W1989211983 @default.
- W1985692169 hasRelatedWork W1997477933 @default.
- W1985692169 hasRelatedWork W2023164490 @default.
- W1985692169 hasRelatedWork W2040139276 @default.
- W1985692169 hasRelatedWork W2069415983 @default.
- W1985692169 hasRelatedWork W2171471341 @default.
- W1985692169 hasRelatedWork W2171567729 @default.
- W1985692169 hasRelatedWork W2474710481 @default.
- W1985692169 hasRelatedWork W4281648102 @default.
- W1985692169 hasRelatedWork W4300934514 @default.
- W1985692169 hasVolume "67" @default.
- W1985692169 isParatext "false" @default.
- W1985692169 isRetracted "false" @default.
- W1985692169 magId "1985692169" @default.
- W1985692169 workType "article" @default.