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- W1985693467 abstract "Abstract Since biomaterial surfaces and their micro and nano structures significantly influence cellular behavior, manipulating the surface characteristics of hydroxyapatite (HA) might potentiallyrepresent a strategy to control cell function. In this study, pure hydroxyapatite with varying microporosity, e.g., 1±0.3% translucent HA(T-HA), 7±0.8% dense HA(D-HA), and 26±1% porous HA(P-HA), were prepared, and biomimic pits were then produced by polishing T-HA and D-HA. The effect of surface pits on cellular behavior was further investigated by analyzing cell adhesion, in addition to cell proliferation and differentiation by co-culturing the materials with MC3T3-E1 cells. We found that the completely dense HA with micropits had the same capacity for cell adhesion, spreading and proliferation, and had a greater capacity for cellular differentiation in vitro than porous HA. Therefore, we believe that polished high-strength, completely dense HA has marked potential in the biomedical applications of tissue engineering due in part to its mechanical and osteoinducible properties." @default.
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- W1985693467 date "2014-09-01" @default.
- W1985693467 modified "2023-09-24" @default.
- W1985693467 title "Modulating cellular behaviors on completely dense hydroxyapatite through biomimic pits" @default.
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- W1985693467 doi "https://doi.org/10.1016/j.ceramint.2014.05.079" @default.
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