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- W1985703062 endingPage "35" @default.
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- W1985703062 abstract "Sensory neurons that innervate the skin provide critical information about physical contact between the organism and the environment, including information about potentially-damaging stimuli that give rise to the sensation of pain. These afferents also contribute to the maintenance of tissue homeostasis, inflammation and wound healing, while sensitization of sensory afferents after injury results in painful hypersensitivity and protective behavior. In contrast to the traditional view of primary afferent terminals as the sole site of sensory transduction, recent reports have lead to the intriguing idea that cells of the skin play an active role in the transduction of sensory stimuli. The search for molecules that transduce different types of sensory stimuli (mechanical, heat, chemical) at the axon terminal has yielded a wide range of potential effectors, many of which are expressed by keratinocytes as well as neurons. Emerging evidence underscores the importance of nucleotide signaling through P2X ionotropic and P2Y metabotropic receptors in pain processing, and implicates nucleotide signaling as a critical form of communication between cells of the skin, immune cells and sensory neurons. It is of great interest to determine whether pathological changes in these mechanisms contribute to chronic pain in human disease states such as complex regional pain syndrome (CRPS). This review discusses recent advances in our understanding of communication mechanisms between cells of the skin and sensory axons in the transduction of sensory input leading to pain." @default.
- W1985703062 created "2016-06-24" @default.
- W1985703062 creator A5008499445 @default.
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- W1985703062 creator A5089614779 @default.
- W1985703062 date "2009-04-01" @default.
- W1985703062 modified "2023-09-25" @default.
- W1985703062 title "Nucleotide signaling and cutaneous mechanisms of pain transduction" @default.
- W1985703062 cites W1503666079 @default.
- W1985703062 cites W1512880472 @default.
- W1985703062 cites W1529421015 @default.
- W1985703062 cites W1544886753 @default.
- W1985703062 cites W1559748532 @default.
- W1985703062 cites W1566638862 @default.
- W1985703062 cites W1623121663 @default.
- W1985703062 cites W1631622699 @default.
- W1985703062 cites W1862246641 @default.
- W1985703062 cites W1893308746 @default.
- W1985703062 cites W1963792755 @default.
- W1985703062 cites W1968311523 @default.
- W1985703062 cites W1969718916 @default.
- W1985703062 cites W1970726646 @default.
- W1985703062 cites W1974516498 @default.
- W1985703062 cites W1977947395 @default.
- W1985703062 cites W1984611108 @default.
- W1985703062 cites W1985254199 @default.
- W1985703062 cites W1988231418 @default.
- W1985703062 cites W1988979613 @default.
- W1985703062 cites W2000832714 @default.
- W1985703062 cites W2003404396 @default.
- W1985703062 cites W2003505114 @default.
- W1985703062 cites W2006962393 @default.
- W1985703062 cites W2010234380 @default.
- W1985703062 cites W2010461365 @default.
- W1985703062 cites W2010505846 @default.
- W1985703062 cites W2013229580 @default.
- W1985703062 cites W2014683303 @default.
- W1985703062 cites W2015395924 @default.
- W1985703062 cites W2020021115 @default.
- W1985703062 cites W2020352730 @default.
- W1985703062 cites W2021116858 @default.
- W1985703062 cites W2021444357 @default.
- W1985703062 cites W2021709312 @default.
- W1985703062 cites W2025853810 @default.
- W1985703062 cites W2027136734 @default.
- W1985703062 cites W2027838428 @default.
- W1985703062 cites W2027981901 @default.
- W1985703062 cites W2030285638 @default.
- W1985703062 cites W2031039258 @default.
- W1985703062 cites W2032485080 @default.
- W1985703062 cites W2035940775 @default.
- W1985703062 cites W2036260428 @default.
- W1985703062 cites W2037011908 @default.
- W1985703062 cites W2039106853 @default.
- W1985703062 cites W2039111221 @default.
- W1985703062 cites W2039457863 @default.
- W1985703062 cites W2040331213 @default.
- W1985703062 cites W2040869238 @default.
- W1985703062 cites W2043373262 @default.
- W1985703062 cites W2043534567 @default.
- W1985703062 cites W2047910499 @default.
- W1985703062 cites W2049018428 @default.
- W1985703062 cites W2050725524 @default.
- W1985703062 cites W2051197065 @default.
- W1985703062 cites W2054024143 @default.
- W1985703062 cites W2055945798 @default.
- W1985703062 cites W2055967275 @default.
- W1985703062 cites W2063980154 @default.
- W1985703062 cites W2064851589 @default.
- W1985703062 cites W2069275960 @default.
- W1985703062 cites W2069644424 @default.
- W1985703062 cites W2070300420 @default.
- W1985703062 cites W2072262931 @default.
- W1985703062 cites W2073566150 @default.
- W1985703062 cites W2074185798 @default.
- W1985703062 cites W2075200978 @default.
- W1985703062 cites W2077939735 @default.
- W1985703062 cites W2081163703 @default.
- W1985703062 cites W2083457444 @default.
- W1985703062 cites W2083509273 @default.
- W1985703062 cites W2083566192 @default.
- W1985703062 cites W2084701217 @default.
- W1985703062 cites W2089613819 @default.
- W1985703062 cites W2090905251 @default.
- W1985703062 cites W2092635728 @default.
- W1985703062 cites W2092791689 @default.
- W1985703062 cites W2092853219 @default.
- W1985703062 cites W2096050960 @default.
- W1985703062 cites W2100241249 @default.
- W1985703062 cites W2100997560 @default.
- W1985703062 cites W2102129421 @default.
- W1985703062 cites W2104675460 @default.
- W1985703062 cites W2107270966 @default.
- W1985703062 cites W2112486201 @default.
- W1985703062 cites W2113565576 @default.
- W1985703062 cites W2116847572 @default.