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- W1985708693 abstract "The hypothalamic paraventricular nucleus (PVN) regulates numerous homeostatic systems and functions largely under the influence of forebrain inputs. Glutamate is a major neurotransmitter in forebrain, and glutamate neurosignaling in the PVN is known to mediate many of its functions. Previous work showed that vesicular glutamate transporters (VGluTs; specific markers for glutamatergic neurons) are expressed in forebrain sites that project to the PVN; however, the extent of this presumed glutamatergic innervation to the PVN is not clear. In the present study retrograde FluoroGold (FG) labeling of PVN-projecting neurons was combined with in situ hybridization for VGluT1 and VGluT2 mRNAs to identify forebrain regions that provide glutamatergic innervation to the PVN and its immediate surround in rats, with special consideration for the sources to the anterior versus posterior PVN. VGluT1 mRNA colocalization with retrogradely labeled FG neurons was sparse. VGluT2 mRNA colocalization with FG neurons was most abundant in the ventromedial hypothalamus after anterior PVN FG injections, and in the lateral, posterior, dorsomedial, and ventromedial hypothalamic nuclei after posterior PVN injections. Anterograde tract tracing combined with VGluT2 immunolabeling showed that 1) ventromedial nucleus-derived glutamatergic inputs occur in both the anterior and posterior PVN; 2) posterior nucleus-derived glutamatergic inputs occur predominantly in the posterior PVN; and 3) medial preoptic nucleus-derived inputs to the PVN are not glutamatergic, thereby corroborating the innervation pattern seen with retrograde tracing. The results suggest that PVN subregions are influenced by varying amounts and sources of forebrain glutamatergic regulation, consistent with functional differentiation of glutamate projections. J. Comp. Neurol. 519:1301–1319, 2011. © 2010 Wiley-Liss, Inc." @default.
- W1985708693 created "2016-06-24" @default.
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- W1985708693 date "2011-03-30" @default.
- W1985708693 modified "2023-10-16" @default.
- W1985708693 title "Forebrain origins of glutamatergic innervation to the rat paraventricular nucleus of the hypothalamus: Differential inputs to the anterior versus posterior subregions" @default.
- W1985708693 cites W1265796269 @default.
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- W1985708693 cites W1556740265 @default.
- W1985708693 cites W1567348707 @default.
- W1985708693 cites W1630907922 @default.
- W1985708693 cites W1646110612 @default.
- W1985708693 cites W1922548155 @default.
- W1985708693 cites W1964912132 @default.
- W1985708693 cites W1966002542 @default.
- W1985708693 cites W1968358098 @default.
- W1985708693 cites W1977741133 @default.
- W1985708693 cites W1979295154 @default.
- W1985708693 cites W1981204355 @default.
- W1985708693 cites W1983511521 @default.
- W1985708693 cites W1988925906 @default.
- W1985708693 cites W1989768591 @default.
- W1985708693 cites W1991206010 @default.
- W1985708693 cites W1992319656 @default.
- W1985708693 cites W2000183296 @default.
- W1985708693 cites W2013586816 @default.
- W1985708693 cites W2014952196 @default.
- W1985708693 cites W2019223615 @default.
- W1985708693 cites W2021158519 @default.
- W1985708693 cites W2023262819 @default.
- W1985708693 cites W2023281207 @default.
- W1985708693 cites W2024505388 @default.
- W1985708693 cites W2029415742 @default.
- W1985708693 cites W2029452109 @default.
- W1985708693 cites W2030807393 @default.
- W1985708693 cites W2031167339 @default.
- W1985708693 cites W2031929672 @default.
- W1985708693 cites W2031951620 @default.
- W1985708693 cites W2033892184 @default.
- W1985708693 cites W2035643315 @default.
- W1985708693 cites W2039080909 @default.
- W1985708693 cites W2041439040 @default.
- W1985708693 cites W2044762872 @default.
- W1985708693 cites W2045171964 @default.
- W1985708693 cites W2045787593 @default.
- W1985708693 cites W2058982402 @default.
- W1985708693 cites W2059648509 @default.
- W1985708693 cites W2060143040 @default.
- W1985708693 cites W2060826007 @default.
- W1985708693 cites W2063771096 @default.
- W1985708693 cites W2065874844 @default.
- W1985708693 cites W2072048191 @default.
- W1985708693 cites W2075236615 @default.
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- W1985708693 cites W2130930589 @default.
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- W1985708693 doi "https://doi.org/10.1002/cne.22571" @default.
- W1985708693 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3893028" @default.
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