FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985709851> ?p ?o ?g. }

• W1985709851 endingPage "205" @default.
• W1985709851 startingPage "197" @default.
• W1985709851 abstract "The major excitatory neurotransmitter in the central nervous system, (S)-glutamic acid , activates both ionotropic and metabotropic excitatory amino acid receptors. Its importance in connection to neurological and psychiatric disorders has directed great attention to the development of compounds that modulate the effects of this endogenous ligand. Whereas L-carboxycyclopropylglycine (L-CCG-1) is a potent agonist at, primarily, group II metabotropic glutamate receptors, alkylation of at the alpha-carbon notoriously result in group II mGluR antagonists, of which the most potent compound described so far, LY341495, displays IC(50) values of 23 and 10 nM at the group II receptor subtypes mGlu2 and mGlu3, respectively. In this study we synthesized a series of structural analogues of in which the xanthyl moiety is replaced by two substituted-phenyl groups. The pharmacological characterization shows that these novel compounds have very high affinity for group II mGluRs when tested as their racemates. The most potent analogues demonstrate K(i) values in the range of 5-12 nM, being thus comparable to LY341495." @default.
• W1985709851 created "2016-06-24" @default.
• W1985709851 creator A5012599330 @default.
• W1985709851 creator A5021325729 @default.
• W1985709851 creator A5028334996 @default.
• W1985709851 creator A5032477659 @default.
• W1985709851 creator A5036532125 @default.
• W1985709851 creator A5039647176 @default.
• W1985709851 creator A5055799927 @default.
• W1985709851 date "2003-01-01" @default.
• W1985709851 modified "2023-09-25" @default.
• W1985709851 title "Synthesis and Structure–Activity Relationship Studies of Novel 2-Diarylethyl Substituted (2-Carboxycycloprop-1-yl)glycines as High-Affinity Group II Metabotropic Glutamate Receptor Ligands" @default.
• W1985709851 cites W1487123995 @default.
• W1985709851 cites W1510964523 @default.
• W1985709851 cites W1551088980 @default.
• W1985709851 cites W1772604871 @default.
• W1985709851 cites W1968479888 @default.
• W1985709851 cites W1970596941 @default.
• W1985709851 cites W1974835335 @default.
• W1985709851 cites W1976289522 @default.
• W1985709851 cites W1978171643 @default.
• W1985709851 cites W1980847901 @default.
• W1985709851 cites W1981754097 @default.
• W1985709851 cites W1982221956 @default.
• W1985709851 cites W1989363688 @default.
• W1985709851 cites W1998614034 @default.
• W1985709851 cites W1999259477 @default.
• W1985709851 cites W2016413308 @default.
• W1985709851 cites W2017505808 @default.
• W1985709851 cites W2025512517 @default.
• W1985709851 cites W2029542833 @default.
• W1985709851 cites W2031125523 @default.
• W1985709851 cites W2037335026 @default.
• W1985709851 cites W2043339467 @default.
• W1985709851 cites W2043873927 @default.
• W1985709851 cites W2052935274 @default.
• W1985709851 cites W2054405716 @default.
• W1985709851 cites W2066439059 @default.
• W1985709851 cites W2067201874 @default.
• W1985709851 cites W2068761941 @default.
• W1985709851 cites W2069338515 @default.
• W1985709851 cites W2080529726 @default.
• W1985709851 cites W2082049028 @default.
• W1985709851 cites W2085477113 @default.
• W1985709851 cites W2091281983 @default.
• W1985709851 cites W2092783437 @default.
• W1985709851 cites W2149201522 @default.
• W1985709851 doi "https://doi.org/10.1016/s0968-0896(02)00387-5" @default.
• W1985709851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12470714" @default.
• W1985709851 hasPublicationYear "2003" @default.
• W1985709851 type Work @default.
• W1985709851 sameAs 1985709851 @default.
• W1985709851 citedByCount "24" @default.
• W1985709851 countsByYear W19857098512013 @default.
• W1985709851 countsByYear W19857098512015 @default.
• W1985709851 countsByYear W19857098512017 @default.
• W1985709851 countsByYear W19857098512018 @default.
• W1985709851 countsByYear W19857098512019 @default.
• W1985709851 countsByYear W19857098512021 @default.
• W1985709851 countsByYear W19857098512022 @default.
• W1985709851 crossrefType "journal-article" @default.
• W1985709851 hasAuthorship W1985709851A5012599330 @default.
• W1985709851 hasAuthorship W1985709851A5021325729 @default.
• W1985709851 hasAuthorship W1985709851A5028334996 @default.
• W1985709851 hasAuthorship W1985709851A5032477659 @default.
• W1985709851 hasAuthorship W1985709851A5036532125 @default.
• W1985709851 hasAuthorship W1985709851A5039647176 @default.
• W1985709851 hasAuthorship W1985709851A5055799927 @default.
• W1985709851 hasConcept C115955781 @default.
• W1985709851 hasConcept C116592611 @default.
• W1985709851 hasConcept C119128870 @default.
• W1985709851 hasConcept C170493617 @default.
• W1985709851 hasConcept C185592680 @default.
• W1985709851 hasConcept C200385062 @default.
• W1985709851 hasConcept C207951395 @default.
• W1985709851 hasConcept C26702167 @default.
• W1985709851 hasConcept C2778938600 @default.
• W1985709851 hasConcept C41653306 @default.
• W1985709851 hasConcept C49051014 @default.
• W1985709851 hasConcept C55493867 @default.
• W1985709851 hasConcept C56940625 @default.
• W1985709851 hasConcept C61174792 @default.
• W1985709851 hasConcept C71240020 @default.
• W1985709851 hasConcept C87247309 @default.
• W1985709851 hasConceptScore W1985709851C115955781 @default.
• W1985709851 hasConceptScore W1985709851C116592611 @default.
• W1985709851 hasConceptScore W1985709851C119128870 @default.
• W1985709851 hasConceptScore W1985709851C170493617 @default.
• W1985709851 hasConceptScore W1985709851C185592680 @default.
• W1985709851 hasConceptScore W1985709851C200385062 @default.
• W1985709851 hasConceptScore W1985709851C207951395 @default.
• W1985709851 hasConceptScore W1985709851C26702167 @default.
• W1985709851 hasConceptScore W1985709851C2778938600 @default.
• W1985709851 hasConceptScore W1985709851C41653306 @default.
• W1985709851 hasConceptScore W1985709851C49051014 @default.
• W1985709851 hasConceptScore W1985709851C55493867 @default.
• W1985709851 hasConceptScore W1985709851C56940625 @default.
• W1985709851 hasConceptScore W1985709851C61174792 @default.

• next