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- W1985711398 abstract "Abstract To study the significance of the endothelial integrity for the accumulation of cholesterol during atherogenesis, the concentration and uptake in vivo of free and esterified cholesterol was determined in regions with intact and defective endothelium in the aorta of normal rabbits. The cholesterol content and the uptake of free and esterified cholesterol was higher in regions with defective endothelium. The higher uptake of esterified cholesterol suggests filtration of lipoproteins in regions with defective endothelium. In regions with intact endothelium, a direct relationship was found between the uptake of labelled free and esterified cholesterol with a ratio between the fractions of 20:1, suggesting active transport of cholesterol involving hydrolysis of cholesteryl ester as a primary step. Furthermore, in the same regions, an inverse relationship was found between uptake and content of cholesterol, suggesting an adjustment of the cholesterol uptake to different requirements in different regions of the aorta. Finally, the results indicate that the intact endothelial lining may represent a structural barrier against the excessive influx of cholesterol, and it is suggested that the integrity of this barrier may be decreased during atherogenesis." @default.
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- W1985711398 date "1973-01-01" @default.
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- W1985711398 title "Cholesterol accumulation and content in regions with defined endothelial integrity in the normal rabbit aorta" @default.
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- W1985711398 doi "https://doi.org/10.1016/0021-9150(73)90136-6" @default.
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