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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985722204> ?p ?o ?g. }

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• W1985722204 abstract "We investigated the effect of human beta-amyloid precursor protein (APP) on rat primary cerebral cortical neurons cultured in a serum-free medium. Two secretory APP species (APP667 and APP592) with and without the protease inhibitor domain were produced by COS-1 cells transfected with APP cDNAs, which encode the N-terminal portions of APP770 and APP695. Both highly purified APP species, when added to the medium, enhanced neuronal survival and neurite extension in a dose-dependent manner with a maximum effect at approximately 100 nM. These results suggest that secreted forms of APP have trophic activity for cerebral cortical neurons." @default.
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• W1985722204 date "1991-11-01" @default.
• W1985722204 modified "2023-10-06" @default.
• W1985722204 title "Trophic effect of β-amyloid precursor protein on cerebral cortical neurons in culture" @default.
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• W1985722204 doi "https://doi.org/10.1016/s0006-291x(05)81412-3" @default.
• W1985722204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1958195" @default.
• W1985722204 hasPublicationYear "1991" @default.
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