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- W1985752008 abstract "Of the more than 100 different human papillomavirus types (HPVs), the high-risk HPVs are associated with the vast majority of cervical carcinoma, and a pathologically distinct group of oropharyngeal tumors. In addition, other HPVs are associated with cutaneous tumors, in particular epidermodysplasia verruciformis and non-melanoma skin cancers. In general, HPV-associated cancers arise from a single accidental integration event of the viral genome into a host cell chromosome. Integration is a terminal event for the viral life cycle. Even though integration does not occur at specific chromosomal hot spots in the human genome, it follows a consistent pattern with respect to the viral genome, and expression of the HPV E6 and E7 genes is consistently retained. The normal function of E6 and E7 is to establish and maintain a cellular milieu that allows for viral genome replication. E6 and E7 target important cellular growth regulatory circuits among them the p53 and retinoblastoma tumor suppressors, respectively. Uncontrolled expression of the E6 and E7 proteins, as a consequence of viral integration is paramount to the establishment and maintenance of the tumorigenic state. In addition, expression of E6 and E7 increases genomic instability of the host cell thus accelerating malignant progression. Taken together, there is compelling molecular and epidemiological evidence in support of an oncogenic function of certain HPVs." @default.
- W1985752008 created "2016-06-24" @default.
- W1985752008 creator A5001039737 @default.
- W1985752008 date "2002-01-01" @default.
- W1985752008 modified "2023-10-11" @default.
- W1985752008 title "The role of human papillomaviruses in human cancers" @default.
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- W1985752008 cites W1537495001 @default.
- W1985752008 cites W1675517407 @default.
- W1985752008 cites W1775859274 @default.
- W1985752008 cites W1828182586 @default.
- W1985752008 cites W1831319429 @default.
- W1985752008 cites W190015672 @default.
- W1985752008 cites W1960826662 @default.
- W1985752008 cites W1967007165 @default.
- W1985752008 cites W1968951719 @default.
- W1985752008 cites W1971653050 @default.
- W1985752008 cites W1971759237 @default.
- W1985752008 cites W1972190437 @default.
- W1985752008 cites W1980377336 @default.
- W1985752008 cites W1992976870 @default.
- W1985752008 cites W1993595140 @default.
- W1985752008 cites W1997161295 @default.
- W1985752008 cites W1999611844 @default.
- W1985752008 cites W2001788009 @default.
- W1985752008 cites W2002158439 @default.
- W1985752008 cites W2003268750 @default.
- W1985752008 cites W2011365922 @default.
- W1985752008 cites W2020658023 @default.
- W1985752008 cites W2029673931 @default.
- W1985752008 cites W2029735450 @default.
- W1985752008 cites W2033998889 @default.
- W1985752008 cites W2034277114 @default.
- W1985752008 cites W2034598992 @default.
- W1985752008 cites W2035040640 @default.
- W1985752008 cites W2038500217 @default.
- W1985752008 cites W2039382131 @default.
- W1985752008 cites W2039899610 @default.
- W1985752008 cites W2039934202 @default.
- W1985752008 cites W2042611229 @default.
- W1985752008 cites W2053818769 @default.
- W1985752008 cites W2053876964 @default.
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- W1985752008 cites W2072581924 @default.
- W1985752008 cites W2075873712 @default.
- W1985752008 cites W2083649409 @default.
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- W1985752008 doi "https://doi.org/10.2741/a800" @default.
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