FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985756543> ?p ?o ?g. }

• W1985756543 endingPage "1109" @default.
• W1985756543 startingPage "1093" @default.
• W1985756543 abstract "Multipotent mesenchymal stromal cells (MSCs) are a promising cell type for cell transplantation; however, their utilization remains limited until the availability of adequate alternative sources of MSCs and the thorough understanding of the biology of MSCs isolated from various sources are realized. Fetal lung has been identified as a rich source of MSCs. To explore the therapeutic potential of passaged fetal lung MSCs (FLMSCs), the present study evaluated their growth kinetics, telomere length, karyotype, immunophenotype, and the differentiation potential during in vitro expansion. FLMSCs could be easily amplified in vitro with no significant shorting of telomere length and had a normal karyotype. No significant differences between passage 5 or passage 25 were observed in the immunophenotype analysis using flow cytometry. Moreover, flow cytometry results provided the first demonstration, to our knowledge, that FLMSCs stably expressed pluripotent markers including Oct4, Nanog, Sox2, TRA-1-60, c-Myc, and SSEA-4 through 25 passages. In vitro differentiation studies as identified by confocal microscopy, flow cytometry, RT-PCR, and immunohistochemistry showed that FLMSCs had extended capacity of differentiating into mesodermal, ectodermal, and endodermal lineages, and that their potential for adipogenic, osteogenic, and chondrogenic differentiation may be maintained over 25 passages. Furthermore, osteogenic and chondrogenic differentiation was used as an indicator of their differentiation capability in vivo, as evidenced by ectopic bone and cartilage formation. In summary, these results suggest that FLMSCs are a primitive population and that their extensive in vitro expansion does not involve significant functional modification of the cells, including morphology, growth, karyotype, immunophenotype, and mesodermal differentiation potential. Hence, FLMSCs might constitute an attractive cell resource for cell transplantation to induce regeneration of damaged tissues/organs." @default.
• W1985756543 created "2016-06-24" @default.
• W1985756543 creator A5004924346 @default.
• W1985756543 creator A5012458625 @default.
• W1985756543 creator A5016883884 @default.
• W1985756543 creator A5032599834 @default.
• W1985756543 creator A5045714102 @default.
• W1985756543 creator A5069469064 @default.
• W1985756543 creator A5070488290 @default.
• W1985756543 date "2009-10-01" @default.
• W1985756543 modified "2023-10-02" @default.
• W1985756543 title "Human Multipotent Mesenchymal Stromal Cells from Fetal Lung Expressing Pluripotent Markers and Differentiating into Cell Types of Three Germ Layers" @default.
• W1985756543 cites W1566246481 @default.
• W1985756543 cites W1964632668 @default.
• W1985756543 cites W1965903389 @default.
• W1985756543 cites W1968145681 @default.
• W1985756543 cites W1969281312 @default.
• W1985756543 cites W1970590929 @default.
• W1985756543 cites W1977407862 @default.
• W1985756543 cites W1979782761 @default.
• W1985756543 cites W1988237668 @default.
• W1985756543 cites W1991328368 @default.
• W1985756543 cites W1994642954 @default.
• W1985756543 cites W2000960050 @default.
• W1985756543 cites W2010137939 @default.
• W1985756543 cites W2014904868 @default.
• W1985756543 cites W2027069467 @default.
• W1985756543 cites W2036966078 @default.
• W1985756543 cites W2040297287 @default.
• W1985756543 cites W2051987080 @default.
• W1985756543 cites W2056804745 @default.
• W1985756543 cites W2058375497 @default.
• W1985756543 cites W2059361866 @default.
• W1985756543 cites W2059880083 @default.
• W1985756543 cites W2061413411 @default.
• W1985756543 cites W2068833559 @default.
• W1985756543 cites W2076186685 @default.
• W1985756543 cites W2077620451 @default.
• W1985756543 cites W2086506814 @default.
• W1985756543 cites W2089997622 @default.
• W1985756543 cites W2093435754 @default.
• W1985756543 cites W2110819175 @default.
• W1985756543 cites W2112427544 @default.
• W1985756543 cites W2113619226 @default.
• W1985756543 cites W2118622683 @default.
• W1985756543 cites W2125987139 @default.
• W1985756543 cites W2126134953 @default.
• W1985756543 cites W2136767600 @default.
• W1985756543 cites W2138577363 @default.
• W1985756543 cites W2141370466 @default.
• W1985756543 cites W2147164277 @default.
• W1985756543 cites W2148842379 @default.
• W1985756543 cites W2154729178 @default.
• W1985756543 cites W2158048826 @default.
• W1985756543 cites W2161715983 @default.
• W1985756543 cites W2164401738 @default.
• W1985756543 cites W2165438231 @default.
• W1985756543 cites W2171292002 @default.
• W1985756543 doi "https://doi.org/10.3727/096368909x12483162197042" @default.
• W1985756543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19650974" @default.
• W1985756543 hasPublicationYear "2009" @default.
• W1985756543 type Work @default.
• W1985756543 sameAs 1985756543 @default.
• W1985756543 citedByCount "36" @default.
• W1985756543 countsByYear W19857565432012 @default.
• W1985756543 countsByYear W19857565432013 @default.
• W1985756543 countsByYear W19857565432014 @default.
• W1985756543 countsByYear W19857565432016 @default.
• W1985756543 countsByYear W19857565432017 @default.
• W1985756543 countsByYear W19857565432018 @default.
• W1985756543 countsByYear W19857565432019 @default.
• W1985756543 countsByYear W19857565432020 @default.
• W1985756543 countsByYear W19857565432021 @default.
• W1985756543 countsByYear W19857565432022 @default.
• W1985756543 countsByYear W19857565432023 @default.
• W1985756543 crossrefType "journal-article" @default.
• W1985756543 hasAuthorship W1985756543A5004924346 @default.
• W1985756543 hasAuthorship W1985756543A5012458625 @default.
• W1985756543 hasAuthorship W1985756543A5016883884 @default.
• W1985756543 hasAuthorship W1985756543A5032599834 @default.
• W1985756543 hasAuthorship W1985756543A5045714102 @default.
• W1985756543 hasAuthorship W1985756543A5069469064 @default.
• W1985756543 hasAuthorship W1985756543A5070488290 @default.
• W1985756543 hasBestOaLocation W19857565431 @default.
• W1985756543 hasConcept C104317684 @default.
• W1985756543 hasConcept C107459253 @default.
• W1985756543 hasConcept C142724271 @default.
• W1985756543 hasConcept C145103041 @default.
• W1985756543 hasConcept C148738053 @default.
• W1985756543 hasConcept C196166836 @default.
• W1985756543 hasConcept C198826908 @default.
• W1985756543 hasConcept C201750760 @default.
• W1985756543 hasConcept C203014093 @default.
• W1985756543 hasConcept C207701140 @default.
• W1985756543 hasConcept C2777933648 @default.
• W1985756543 hasConcept C28328180 @default.
• W1985756543 hasConcept C2908647359 @default.
• W1985756543 hasConcept C2910776680 @default.

• next