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- W1985758547 abstract "Abstract Reptilase induces in the thrombelastograph (TEG) plasma clots which are different from those formed by thrombin. Platelets promote the structuration of both reptilase - and thrombin-fibrin. ADP or other aggregating substances, although not primarily involved in the interaction of platelets with reptilase-fibrin, considerably increase such interaction; indeed, in their presence, the clot formation time (k) is shortened and the maximal amplitude of TEG strongly increased. The promoting effect of aggregating agents (including thrombin) on the structuration of fibrin is inhibited by several aggregation inhibitors (Na2-EDTA, pyrimido-pyrimidine compounds, PGE1). In contrast, both aspirin and indomethacin are ineffective. It is suggested that the role of platelets in clot structuration is, at least, twofold: 1) adherence of polymerising fibrin to platelets orients the fibrin fibres; 2) activation of the platelet contractile system provides further orientation of the fibrin fibres and increases their tensile strength. In all the systems studied, the maximal amplitude of TEG was linearly related to the degree of clot retraction; this confirms that the maximal amplitude of TEG is a measure of clot retraction. Provided conditions for the basic fibrin structure (qualitatively and quantitatively) are equal." @default.
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- W1985758547 date "1973-10-01" @default.
- W1985758547 modified "2023-09-27" @default.
- W1985758547 title "Effect of platelets on clot structuration. A thrombelastographic study" @default.
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- W1985758547 doi "https://doi.org/10.1016/0049-3848(73)90037-6" @default.
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