FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985759871> ?p ?o ?g. }

• W1985759871 endingPage "15123" @default.
• W1985759871 startingPage "15119" @default.
• W1985759871 abstract "Voltage-gated K+ channels are complexes of membrane-bound, ion-conducting alpha and cytoplasmic ancillary (beta) subunits. The primary physiologic effect of coexpression of alpha and beta subunits is to increase the intrinsic rate of inactivation of the alpha subunit. For one beta subunit, Kv beta 1.1, inactivation is enhanced through an N-type mechanism. A second beta subunit, Kv beta 1.2, has been shown to increase inactivation, but through a distinct mechanism. Here we show that the degree of enhancement of Kv beta 1.2 inactivation is dependent on the amino acid composition in the pore mouth of the alpha subunit and the concentration of extracellular K+. Experimental conditions that promote C-type inactivation also enhance the stimulation of inactivation by Kv beta 1.2, showing that this beta subunit directly stimulates C-type inactivation. Chimeric constructs containing just the nonconserved N-terminal region of Kv beta 1.2 fused with an alpha subunit behave in a similar fashion to coexpressed Kv beta 1.2 and alpha subunit. This shows that it is the N-terminal domain of Kv beta 1.2 that mediates the increase in C-type inactivation from the cytoplasmic side of the pore. We propose a model whereby the N terminus of Kv beta 1.2 acts as a weakly binding ball domain that associates with the intracellular vestibule of the alpha subunit to effect a conformational change leading to enhancement of C-type inactivation." @default.
• W1985759871 created "2016-06-24" @default.
• W1985759871 creator A5029686920 @default.
• W1985759871 creator A5053248517 @default.
• W1985759871 creator A5058017240 @default.
• W1985759871 creator A5078433523 @default.
• W1985759871 creator A5090940191 @default.
• W1985759871 date "1996-12-24" @default.
• W1985759871 modified "2023-10-10" @default.
• W1985759871 title "The N-terminal domain of a K ⁺ channel β subunit increases the rate of C-type inactivation from the cytoplasmic side of the channel" @default.
• W1985759871 cites W1233451781 @default.
• W1985759871 cites W1600171386 @default.
• W1985759871 cites W1696719218 @default.
• W1985759871 cites W1811413146 @default.
• W1985759871 cites W1966667742 @default.
• W1985759871 cites W1969870358 @default.
• W1985759871 cites W1972882396 @default.
• W1985759871 cites W1981797636 @default.
• W1985759871 cites W1987182471 @default.
• W1985759871 cites W2007832680 @default.
• W1985759871 cites W2027808289 @default.
• W1985759871 cites W2034126125 @default.
• W1985759871 cites W2047258134 @default.
• W1985759871 cites W2053930832 @default.
• W1985759871 cites W2059957319 @default.
• W1985759871 cites W2068732182 @default.
• W1985759871 cites W2072972683 @default.
• W1985759871 cites W2082585200 @default.
• W1985759871 cites W2083088703 @default.
• W1985759871 cites W2086172025 @default.
• W1985759871 cites W2101625991 @default.
• W1985759871 cites W2108765087 @default.
• W1985759871 cites W2165830038 @default.
• W1985759871 cites W2416389912 @default.
• W1985759871 cites W2427612437 @default.
• W1985759871 cites W4285719527 @default.
• W1985759871 doi "https://doi.org/10.1073/pnas.93.26.15119" @default.
• W1985759871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/26366" @default.
• W1985759871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9005448" @default.
• W1985759871 hasPublicationYear "1996" @default.
• W1985759871 type Work @default.
• W1985759871 sameAs 1985759871 @default.
• W1985759871 citedByCount "44" @default.
• W1985759871 countsByYear W19857598712013 @default.
• W1985759871 countsByYear W19857598712014 @default.
• W1985759871 countsByYear W19857598712015 @default.
• W1985759871 countsByYear W19857598712018 @default.
• W1985759871 countsByYear W19857598712020 @default.
• W1985759871 crossrefType "journal-article" @default.
• W1985759871 hasAuthorship W1985759871A5029686920 @default.
• W1985759871 hasAuthorship W1985759871A5053248517 @default.
• W1985759871 hasAuthorship W1985759871A5058017240 @default.
• W1985759871 hasAuthorship W1985759871A5078433523 @default.
• W1985759871 hasAuthorship W1985759871A5090940191 @default.
• W1985759871 hasBestOaLocation W19857598712 @default.
• W1985759871 hasConcept C104292427 @default.
• W1985759871 hasConcept C104317684 @default.
• W1985759871 hasConcept C12554922 @default.
• W1985759871 hasConcept C185592680 @default.
• W1985759871 hasConcept C190062978 @default.
• W1985759871 hasConcept C199360897 @default.
• W1985759871 hasConcept C206412730 @default.
• W1985759871 hasConcept C2776174256 @default.
• W1985759871 hasConcept C41008148 @default.
• W1985759871 hasConcept C55493867 @default.
• W1985759871 hasConcept C79879829 @default.
• W1985759871 hasConcept C83730767 @default.
• W1985759871 hasConcept C86803240 @default.
• W1985759871 hasConceptScore W1985759871C104292427 @default.
• W1985759871 hasConceptScore W1985759871C104317684 @default.
• W1985759871 hasConceptScore W1985759871C12554922 @default.
• W1985759871 hasConceptScore W1985759871C185592680 @default.
• W1985759871 hasConceptScore W1985759871C190062978 @default.
• W1985759871 hasConceptScore W1985759871C199360897 @default.
• W1985759871 hasConceptScore W1985759871C206412730 @default.
• W1985759871 hasConceptScore W1985759871C2776174256 @default.
• W1985759871 hasConceptScore W1985759871C41008148 @default.
• W1985759871 hasConceptScore W1985759871C55493867 @default.
• W1985759871 hasConceptScore W1985759871C79879829 @default.
• W1985759871 hasConceptScore W1985759871C83730767 @default.
• W1985759871 hasConceptScore W1985759871C86803240 @default.
• W1985759871 hasIssue "26" @default.
• W1985759871 hasLocation W19857598711 @default.
• W1985759871 hasLocation W19857598712 @default.
• W1985759871 hasLocation W19857598713 @default.
• W1985759871 hasLocation W19857598714 @default.
• W1985759871 hasOpenAccess W1985759871 @default.
• W1985759871 hasPrimaryLocation W19857598711 @default.
• W1985759871 hasRelatedWork W1512964098 @default.
• W1985759871 hasRelatedWork W1536809633 @default.
• W1985759871 hasRelatedWork W1600137682 @default.
• W1985759871 hasRelatedWork W1784526106 @default.
• W1985759871 hasRelatedWork W1941570059 @default.
• W1985759871 hasRelatedWork W1978515640 @default.
• W1985759871 hasRelatedWork W2065411374 @default.
• W1985759871 hasRelatedWork W2183838695 @default.
• W1985759871 hasRelatedWork W2325795238 @default.
• W1985759871 hasRelatedWork W4254186660 @default.

• next