FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985772582> ?p ?o ?g. }

• W1985772582 endingPage "768" @default.
• W1985772582 startingPage "763" @default.
• W1985772582 abstract "1. We examined the effects of a selective endothelin A (ETA)-receptor antagonist, BQ-123, on the development of hypertension and organ damage in stroke-prone spontaneously hypertensive rats (SHRSP) given 1% NaCl for 6 weeks. 2. BQ-123 at doses of 0.7, 2.1 and 7.1 mg/day was continuously administered for 6 weeks to 8 week old salt-loaded SHRSP, who were given water containing 1% NaCl for the following 6 weeks, via a subcutaneous osmotic minipump. 3. Development of high blood pressure was accelerated in salt-loaded SHRSP compared with that in non-salt-loaded SHRSP. After 6 weeks of salt-loading, incidence of cerebral infarction, renal sclerosis and renal fibrosis were greater in salt-loaded than non-salt-loaded SHRSP. 4. BQ-123 attenuated the age-related rise in blood pressure in a dose-dependent manner. The effect coincided with reduction in the incidence of cerebral infarction and prevention of renal sclerosis and fibrosis. Kidney function was improved as observed by an increase in glomerular filtration rate and decreases in urinary protein excretion, blood urea nitrogen and fractional sodium excretion. Furthermore, BQ-123 prevented increases in the heart weight/bodyweight ratio and aortic wall thickness in salt-loaded SHRSP. 5. These results suggest that endogenous endothelin-1 (ET-1) and ETA-receptors may be, at least in part, involved in the pathogenesis of hypertension and organ damage in salt-loaded SHRSP." @default.
• W1985772582 created "2016-06-24" @default.
• W1985772582 creator A5020319663 @default.
• W1985772582 creator A5023678652 @default.
• W1985772582 creator A5025633448 @default.
• W1985772582 creator A5043693065 @default.
• W1985772582 creator A5043704885 @default.
• W1985772582 creator A5070608779 @default.
• W1985772582 creator A5078689987 @default.
• W1985772582 date "1995-10-01" @default.
• W1985772582 modified "2023-10-17" @default.
• W1985772582 title "EFFECTS OF A SELECTIVE ENDOTHELIN A-RECEPTOR ANTAGONIST, BQ-123, IN SALT-LOADED STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS" @default.
• W1985772582 cites W1588320719 @default.
• W1985772582 cites W1931134866 @default.
• W1985772582 cites W1965088568 @default.
• W1985772582 cites W1973929461 @default.
• W1985772582 cites W1974579801 @default.
• W1985772582 cites W1977314462 @default.
• W1985772582 cites W1982433562 @default.
• W1985772582 cites W1989355270 @default.
• W1985772582 cites W1990570083 @default.
• W1985772582 cites W2028256223 @default.
• W1985772582 cites W2032464790 @default.
• W1985772582 cites W2056966654 @default.
• W1985772582 cites W2062329497 @default.
• W1985772582 cites W2074248400 @default.
• W1985772582 cites W2077181129 @default.
• W1985772582 cites W2079265799 @default.
• W1985772582 cites W2083834362 @default.
• W1985772582 cites W2084424941 @default.
• W1985772582 cites W2089930218 @default.
• W1985772582 cites W2093655696 @default.
• W1985772582 cites W2097100633 @default.
• W1985772582 cites W2128903833 @default.
• W1985772582 cites W2133040751 @default.
• W1985772582 cites W2135875162 @default.
• W1985772582 cites W2147554218 @default.
• W1985772582 cites W2162804111 @default.
• W1985772582 cites W2170317646 @default.
• W1985772582 cites W2313969287 @default.
• W1985772582 cites W2886053949 @default.
• W1985772582 cites W4256593530 @default.
• W1985772582 doi "https://doi.org/10.1111/j.1440-1681.1995.tb01932.x" @default.
• W1985772582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8575114" @default.
• W1985772582 hasPublicationYear "1995" @default.
• W1985772582 type Work @default.
• W1985772582 sameAs 1985772582 @default.
• W1985772582 citedByCount "24" @default.
• W1985772582 countsByYear W19857725822018 @default.
• W1985772582 countsByYear W19857725822019 @default.
• W1985772582 countsByYear W19857725822021 @default.
• W1985772582 crossrefType "journal-article" @default.
• W1985772582 hasAuthorship W1985772582A5020319663 @default.
• W1985772582 hasAuthorship W1985772582A5023678652 @default.
• W1985772582 hasAuthorship W1985772582A5025633448 @default.
• W1985772582 hasAuthorship W1985772582A5043693065 @default.
• W1985772582 hasAuthorship W1985772582A5043704885 @default.
• W1985772582 hasAuthorship W1985772582A5070608779 @default.
• W1985772582 hasAuthorship W1985772582A5078689987 @default.
• W1985772582 hasConcept C10146269 @default.
• W1985772582 hasConcept C126322002 @default.
• W1985772582 hasConcept C127413603 @default.
• W1985772582 hasConcept C134018914 @default.
• W1985772582 hasConcept C144980905 @default.
• W1985772582 hasConcept C159641895 @default.
• W1985772582 hasConcept C170493617 @default.
• W1985772582 hasConcept C185592680 @default.
• W1985772582 hasConcept C2776345702 @default.
• W1985772582 hasConcept C2776885963 @default.
• W1985772582 hasConcept C2778176769 @default.
• W1985772582 hasConcept C2780091579 @default.
• W1985772582 hasConcept C2780645631 @default.
• W1985772582 hasConcept C71924100 @default.
• W1985772582 hasConcept C78519656 @default.
• W1985772582 hasConcept C84393581 @default.
• W1985772582 hasConceptScore W1985772582C10146269 @default.
• W1985772582 hasConceptScore W1985772582C126322002 @default.
• W1985772582 hasConceptScore W1985772582C127413603 @default.
• W1985772582 hasConceptScore W1985772582C134018914 @default.
• W1985772582 hasConceptScore W1985772582C144980905 @default.
• W1985772582 hasConceptScore W1985772582C159641895 @default.
• W1985772582 hasConceptScore W1985772582C170493617 @default.
• W1985772582 hasConceptScore W1985772582C185592680 @default.
• W1985772582 hasConceptScore W1985772582C2776345702 @default.
• W1985772582 hasConceptScore W1985772582C2776885963 @default.
• W1985772582 hasConceptScore W1985772582C2778176769 @default.
• W1985772582 hasConceptScore W1985772582C2780091579 @default.
• W1985772582 hasConceptScore W1985772582C2780645631 @default.
• W1985772582 hasConceptScore W1985772582C71924100 @default.
• W1985772582 hasConceptScore W1985772582C78519656 @default.
• W1985772582 hasConceptScore W1985772582C84393581 @default.
• W1985772582 hasIssue "10" @default.
• W1985772582 hasLocation W19857725821 @default.
• W1985772582 hasLocation W19857725822 @default.
• W1985772582 hasOpenAccess W1985772582 @default.
• W1985772582 hasPrimaryLocation W19857725821 @default.
• W1985772582 hasRelatedWork W1978867866 @default.
• W1985772582 hasRelatedWork W2001933224 @default.

• next