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• W1985777017 abstract "The increasing availability of genomic sequence from multiple organisms has provided biomedical scientists with a large dataset for orthologous-sequence comparisons. The rationale for using cross-species sequence comparisons to identify biologically active regions of a genome is based on the observation that sequences that perform important functions are frequently conserved between evolutionarily distant species, distinguishing them from nonfunctional surrounding sequences. This is most readily apparent for protein-encoding sequences but also holds true for the sequences involved in the regulation of gene expression. While these observations have frequently been made retrospectively following the analysis of previously discovered genes or gene-regulatory sequences, examination of orthologous genomic sequences from several vertebrates has shown that the inverse is also true. Specifically, studying evolutionarily conserved sequences is a reliable strategy to uncover regions of the human genome with biological activity. To assist biomedical investigators in taking advantage of this new paradigm, various comparative sequence-based visualization tools and databases have been developed. Already, these new publicly accessible resources have been successfully exploited by investigators for the discovery of biomedically important new genes and sequences involved in gene regulation." @default.
• W1985777017 created "2016-06-24" @default.
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• W1985777017 date "2003-04-15" @default.
• W1985777017 modified "2023-10-16" @default.
• W1985777017 title "Comparative genomic tools and databases: providing insights into the human genome" @default.
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• W1985777017 doi "https://doi.org/10.1172/jci200317842" @default.
• W1985777017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/152942" @default.
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