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- W1985791663 abstract "Previous studies have shown statistically significant circadian rhythms in thromboxane and prostacyclin production, platelet aggregation, clotting and fibrinolytic inhibitors, and the inhibition of platelet aggregation produced by aspirin (ASA). ASA has also been shown to produce a dose and administration time-dependent inhibition of angiotensin II. Moreover, an administration time-dependent effect of low-dose ASA on blood pressure (BP) has been previously documented in normotensive volunteers, patients with mild hypertension, and pregnant women at high risk for preeclampsia [Hypertension. 2003;41:651–6; 2003;41:1259–67]. We have extended these results by investigating the potential influence of ASA on BP in previously untreated hypertensive patients who received ASA at different times of the day according to their rest-activity cycle. We studied 287 untreated patients with grade 1 hypertension (110 men), 43.8±12.8 years of age, randomly divided in 3 groups: non-pharmacological hygienic-dietary recommendations (HDR); the same HDR and ASA (100 mg/day) on awakening; or HDR and ASA (100 mg/day) before bedtime. BP and heart rate (HR) were measured by ambulatory monitoring at 20-min intervals from 07:00 to 23:00 hours and at 30-min intervals at night for 48 consecutive hours at baseline and after 3 months of intervention. After 3 months of HDR, there was a small and non-significant reduction of BP (0.4 and 0.5 mm Hg for systolic and diastolic BP; P>0.244). BP was slightly elevated after ASA on awakening, mainly during nocturnal hours (increase of 2.3 and 1.4 mm Hg in the 24-hour mean of systolic and diastolic BP; P<0.029). A highly significant BP reduction was, however, observed in the patients who received ASA before bedtime (decrease of 6.6 and 4.4 mm Hg in systolic and diastolic BP, respectively; P<0.001). This prospective trial corroborates the highly significant administration time-dependent effect of low-dose ASA on BP in untreated patients with grade 1 hypertension. Results indicate that the timed administration of low-dose ASA with respect to the rest-activity cycle of each patient could provide a valuable approach not just for the secondary prevention of cardiovascular disease, but also in the added BP control of patients with mild hypertension and poor compliance with HDR. Am J Hypertens (2004) 17, 40A–41A; doi: 10.1016/j.amjhyper.2004.03.096" @default.
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- W1985791663 date "2004-05-01" @default.
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- W1985791663 title "Administration time-dependent effects of low-dose aspirin on ambulatory blood pressure in grade 1 hypertensive patients" @default.
- W1985791663 doi "https://doi.org/10.1016/j.amjhyper.2004.03.096" @default.
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