Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985793033> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1985793033 endingPage "16" @default.
- W1985793033 startingPage "9" @default.
- W1985793033 abstract "A particle engineering method that adsorbs a microfine vinyl polymer coat to crystalline drug microparticles has been shown to be an effective way to control delivery. However, the means by which the functional performance of such microparticles is altered by the behaviour of the polymers in the microparticle coat remains unclear. The aim of this study was to determine the influence of vinyl polymer coating on the in vitro delivery characteristics of intranasal lorazepam microparticles. A series of four, similarly sized (ca. 10 μm), lorazepam-rich microparticles with different polymer coats were generated. The absorption of the polymer coats appeared to disrupt lorazepam solid state dimer formation in the microparticles, which manifested in a reduction in drug melting point. Mildly cohesive particles (aerodynamic diameter of 32 μm) that allowed rapid drug release (ca. 80% in 5 min) were generated when partially hydrolysed PVA dominated the microparticle coat, whilst fully hydrolysed PVA reduced particle cohesion and retarded drug release (ca. 15% release in 5 min). Infrared analysis showed that the properties of the microparticles were dictated by the strength of the hydrogen bonding in the polymer coat and not the strength of coat adsorption that was facilitated by hydrogen bond formation between the hydroxyl groups of the PVA and the hydroxyl group at position C3 of the lorazepam diazepine ring." @default.
- W1985793033 created "2016-06-24" @default.
- W1985793033 creator A5024358940 @default.
- W1985793033 creator A5028608650 @default.
- W1985793033 creator A5044315228 @default.
- W1985793033 creator A5046419633 @default.
- W1985793033 date "2011-05-01" @default.
- W1985793033 modified "2023-09-27" @default.
- W1985793033 title "Vinyl polymer-coated lorazepam particles for drug delivery to the airways" @default.
- W1985793033 cites W1482464203 @default.
- W1985793033 cites W1503822147 @default.
- W1985793033 cites W189481591 @default.
- W1985793033 cites W1980803266 @default.
- W1985793033 cites W1986860514 @default.
- W1985793033 cites W1991797690 @default.
- W1985793033 cites W2006759883 @default.
- W1985793033 cites W2033399819 @default.
- W1985793033 cites W2042182312 @default.
- W1985793033 cites W2054965106 @default.
- W1985793033 cites W2060164864 @default.
- W1985793033 cites W2069731230 @default.
- W1985793033 cites W207190506 @default.
- W1985793033 cites W2073257728 @default.
- W1985793033 cites W2073976532 @default.
- W1985793033 cites W2076685451 @default.
- W1985793033 cites W2078367818 @default.
- W1985793033 cites W2078683699 @default.
- W1985793033 cites W2083434824 @default.
- W1985793033 cites W2084628698 @default.
- W1985793033 cites W2086776758 @default.
- W1985793033 cites W2089575516 @default.
- W1985793033 cites W2101883647 @default.
- W1985793033 cites W2108174879 @default.
- W1985793033 cites W2138003688 @default.
- W1985793033 cites W2143303707 @default.
- W1985793033 cites W2415412480 @default.
- W1985793033 doi "https://doi.org/10.1016/j.ijpharm.2011.02.053" @default.
- W1985793033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21371546" @default.
- W1985793033 hasPublicationYear "2011" @default.
- W1985793033 type Work @default.
- W1985793033 sameAs 1985793033 @default.
- W1985793033 citedByCount "14" @default.
- W1985793033 countsByYear W19857930332012 @default.
- W1985793033 countsByYear W19857930332013 @default.
- W1985793033 countsByYear W19857930332014 @default.
- W1985793033 countsByYear W19857930332015 @default.
- W1985793033 countsByYear W19857930332017 @default.
- W1985793033 countsByYear W19857930332019 @default.
- W1985793033 countsByYear W19857930332020 @default.
- W1985793033 crossrefType "journal-article" @default.
- W1985793033 hasAuthorship W1985793033A5024358940 @default.
- W1985793033 hasAuthorship W1985793033A5028608650 @default.
- W1985793033 hasAuthorship W1985793033A5044315228 @default.
- W1985793033 hasAuthorship W1985793033A5046419633 @default.
- W1985793033 hasBestOaLocation W19857930332 @default.
- W1985793033 hasConcept C127413603 @default.
- W1985793033 hasConcept C178790620 @default.
- W1985793033 hasConcept C185592680 @default.
- W1985793033 hasConcept C188027245 @default.
- W1985793033 hasConcept C192562407 @default.
- W1985793033 hasConcept C2777521759 @default.
- W1985793033 hasConcept C2779820397 @default.
- W1985793033 hasConcept C42360764 @default.
- W1985793033 hasConcept C521977710 @default.
- W1985793033 hasConceptScore W1985793033C127413603 @default.
- W1985793033 hasConceptScore W1985793033C178790620 @default.
- W1985793033 hasConceptScore W1985793033C185592680 @default.
- W1985793033 hasConceptScore W1985793033C188027245 @default.
- W1985793033 hasConceptScore W1985793033C192562407 @default.
- W1985793033 hasConceptScore W1985793033C2777521759 @default.
- W1985793033 hasConceptScore W1985793033C2779820397 @default.
- W1985793033 hasConceptScore W1985793033C42360764 @default.
- W1985793033 hasConceptScore W1985793033C521977710 @default.
- W1985793033 hasIssue "1-2" @default.
- W1985793033 hasLocation W19857930331 @default.
- W1985793033 hasLocation W19857930332 @default.
- W1985793033 hasLocation W19857930333 @default.
- W1985793033 hasOpenAccess W1985793033 @default.
- W1985793033 hasPrimaryLocation W19857930331 @default.
- W1985793033 hasRelatedWork W2027219165 @default.
- W1985793033 hasRelatedWork W2040489707 @default.
- W1985793033 hasRelatedWork W2048428464 @default.
- W1985793033 hasRelatedWork W2080835752 @default.
- W1985793033 hasRelatedWork W2140018368 @default.
- W1985793033 hasRelatedWork W2366076914 @default.
- W1985793033 hasRelatedWork W2748952813 @default.
- W1985793033 hasRelatedWork W2899084033 @default.
- W1985793033 hasRelatedWork W3090434260 @default.
- W1985793033 hasRelatedWork W3179091597 @default.
- W1985793033 hasVolume "410" @default.
- W1985793033 isParatext "false" @default.
- W1985793033 isRetracted "false" @default.
- W1985793033 magId "1985793033" @default.
- W1985793033 workType "article" @default.