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• W1985799479 startingPage "293" @default.
• W1985799479 abstract "Transforming growth factor alpha (TGF-α) is a single chain polypeptide which exists in a variety of forms differing in molecular weight. These forms are variously present in normal and neoplastic cells. Of particular interest are TGF-α's well-known mitogenic properties. The transition from a normal to a neoplastic cellular state results from signalling defects that may depend upon, iter alia, abonormal levels of expression and secretion of TGF-α. It is known that the secretion of TGF-α may be enhanced appreciably by agents such as phorbol 12-myristate 13-acetate (PMA), serum factors and epidermal growth factor (EGF). Here, we compare the efficacy of these three agents in the elevation of TGF-α secretion in the well studied A431 cell line with their previously undocumented efficacy in certain interesting, but little known, human oesophageal squamous cell carcinoma (SCC) lines." @default.
• W1985799479 created "2016-06-24" @default.
• W1985799479 creator A5031437676 @default.
• W1985799479 creator A5078702879 @default.
• W1985799479 date "1992-08-01" @default.
• W1985799479 modified "2023-09-27" @default.
• W1985799479 title "In vitro secretion of transforming growth factor alpha (TGF-α): A comparison of the A431 cell line with three human oesophageal squamous cell carcinoma lines" @default.
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• W1985799479 doi "https://doi.org/10.1007/bf01122801" @default.
• W1985799479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1421058" @default.
• W1985799479 hasPublicationYear "1992" @default.
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