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• W1985802554 startingPage "3203" @default.
• W1985802554 abstract "Measles-associated mortality can be decreased in response to treatment with vitamin A. Our goal was to understand the mechanism by which vitamin A and other retinoids reduce measles virus (MeV) replication in vitro. MeV is known to inhibit type I interferon (IFN) signaling, and retinoids are increasingly implicated in modulating innate immunity. Type I IFN blocking antibodies abrogated the inhibitory effects of all-trans retinoic acid (ATRA) on MeV replication (EC(50) of ATRA: 3.17 x 10(-8) M). IFN-stimulated genes (ISGs) are up-regulated by ATRA in MeV-infected U937 cell cultures starting at 12 h and reaching a plateau at 24 h postinfection when compared to either treatment or infection alone. We found that this increased gene expression occurs in uninfected cells by using a transwell system where the uninfected cells were separated from infected cells by a membrane with 0.02-muM pores. Uninfected bystander cells from the ATRA-treated transwells did not support substantial viral replication when subsequently infected with MeV. In the absence of ATRA, the cells from the uninfected chamber did not up-regulate ISG expression and were not protected from subsequent challenge with virus. These results demonstrate that retinoids inhibit MeV replication by up-regulating elements of the innate immune response in uninfected bystander cells, making them refractory to productive infection during subsequent rounds of viral replication." @default.
• W1985802554 created "2016-06-24" @default.
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• W1985802554 date "2009-05-15" @default.
• W1985802554 modified "2023-10-02" @default.
• W1985802554 title "Retinoids inhibit measles virus through a type I IFN‐dependent bystander effect" @default.
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• W1985802554 doi "https://doi.org/10.1096/fj.09-129288" @default.
• W1985802554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19447880" @default.
• W1985802554 hasPublicationYear "2009" @default.
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