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- W1985812323 abstract "The bioavailability after oral administration of two sustained release ibuprofen formulations using xanthan gum and a combination of n-octenylsuccinate starch (CL490) and xanthan gum has been investigated in healthy human volunteers and compared with a commercial suspension formulation. The ibuprofen-xanthan gum and the ibuprofen-xanthan gum-CL490 matrix tablets were prepared by direct compression. Three different xanthan gum/CL490 ratios (1:1; 1:4 and 1:10) were investigated in vitro. The xanthan gum/CL490 matrix tablets of a 14 and a 110 ratio both released nearly 100% after 24 h. No difference was observed in the release profiles between the matrix tablets prepared with 11 ratio of xanthan gum and CL490 and with pure xanthan gum during the first 8 h of dissolution test. After 8 h, the release rate from the pure xanthan gum matrix increased (nearly 90% after 24 h) while matrix tablet with a 11 ratio of xanthan gum and CL490 released 60% after 24 h. A dry core remained after a 24 h dissolution time period for matrix tablets prepared with the 11 ratio of xanthan gum and CL490, while the pure xanthan gum matrix had completely eroded. For the in vivo study, a xanthan gum/CL490 (1:1) matrix tablet was compared to a xanthan gum matrix tablet and a conventional suspension formulation. In comparison with the conventional suspension, the oral bioavailability was 86.83% ± 25.80% (n = 6) and 75.50% ± 17.18% (n = 6) for the tablets made with xanthan gum and with a combination of xanthan gum and CL490 (ratio 11), respectively. The combination of a xanthan gum and CL490 seemed to avoid the initial slow absorption phase in vivo that occurred with a pure xanthan gum matrix tablet. The combination of xanthan gum and n-octenylsuccinate starch could offer some advantages in the formulation of sustained release hydrophilic matrix tablets." @default.
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- W1985812323 date "1996-08-01" @default.
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- W1985812323 title "In vitro and in vivo evaluation of a xanthan gum-n-octenylsuccinate starch matrix tablet containing ibuprofen as a model drug" @default.
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- W1985812323 doi "https://doi.org/10.1016/0378-5173(96)04575-9" @default.
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