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- W1985840012 abstract "The dissociation of an in vivo isosafrole metabolite-cytochrome P-450 complex by a number of exogenous and endogenous compounds is described. The rate of dissociation is temperature-dependent, but the process does not require oxygen. Compounds which produce Type I (substrate) binding spectra with oxidized cytochrome P-450 facilitate displacement of the isosafrole metabolite from cytochrome P-450 whereas Type II (ligand-binding) compounds do not dissociate the complex. The factors necessary for dissociation of the complex are discussed and a model for the isosafrole metabolite-cytochrome P-450 complex is proposed." @default.
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- W1985840012 title "Further studies on the dissociation of the isosafrole metabolite-cytochrome p-450 complex" @default.
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- W1985840012 doi "https://doi.org/10.1016/0006-2952(79)90509-4" @default.
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