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• W1985843923 abstract "To evaluate the cumulative singleton live birth rate after classic ovulation induction in women with anovulatory polycystic ovary syndrome and to validate a previously developed prediction model.Prospective follow-up study.Tertiary infertility unit.Validation cohort of 108 treatment-naïve anovulatory PCOS patients.Conventional ovulation induction, applying clomiphene citrate as first-line treatment, followed by exogenous gonadotropins as second-line intervention.Singleton live birth prediction. Model calibration and discrimination were assessed for the initial model (variables included age, duration of infertility, and insulin/glucose ratio) and a second model in which the insulin/glucose ratio was replaced by body mass index.The cumulative singleton live birth rate after 12 and 24 months was 60% and 78%, respectively. Overall, the observed rates were higher than predicted: hazard ratio 1.21 (95% confidence interval [CI] 0.89, 1.64), first model and 1.25 (95% CI 1.20, 1.30), second model. However, the predictive capacity of the model variables was reliable, with calibration slopes of 0.79 (95% CI -0.04, 1.63) and 1.06 (95% CI 0.95, 1.18), respectively.The present study confirms the previously reported good treatment prognosis for women with PCOS undergoing classic ovulation induction. Women with a poor prognosis, for whom alternative treatment options may be considered, can best be identified by a prediction model including age, duration of infertility, and body mass index.NCT00821379." @default.
• W1985843923 created "2016-06-24" @default.
• W1985843923 creator A5008642346 @default.
• W1985843923 creator A5056077573 @default.
• W1985843923 creator A5077162723 @default.
• W1985843923 date "2012-09-01" @default.
• W1985843923 modified "2023-09-28" @default.
• W1985843923 title "High singleton live birth rate confirmed after ovulation induction in women with anovulatory polycystic ovary syndrome: validation of a prediction model for clinical practice" @default.
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• W1985843923 doi "https://doi.org/10.1016/j.fertnstert.2012.04.027" @default.
• W1985843923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22633255" @default.
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