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• W1985845811 abstract "Successful Helicobacter pylori (H.pylori) treatment has been reported to predispose to the development of reflux esophagitis (RE). However, despite this evidence, to date no attention had been paid to the time trend for the appearance of RE after H.pylori treatment. This information could be of importance in dealing with patient management after eradication. The aim of this prospective study therefore was two fold. Firstly, to examine the RE rate after H.pylori eradication and secondly, to study the time trend for the appearance of RE. Methods: 50 consecutive, successfully eradicated patients, without RE at the time of H.pylori treatment [25 duodenal ulcer (DU) and 25 non-ulcer (NU), 30M, 20F, median age 41.5 yrs, range 21-57] were followed up for 24 months after H.pylori eradication or when reflux symptoms occurred. The chi-square test for trend and the life table analysis were performed for calculating the incidence and time trend for RE appearance after H.pylori eradication. Patients were censored if the end point was reached or if RE was noted at endoscopy. Results: Among the 50 H.pylori(+) successfully treated patients, 12/50(24%) developed RE during the 24 month follow up period. In 9/12 patients(75%), RE developed during the first year of the follow up, at months 5,6,7,9,10,11 and 12 (respective percentages of patients without RE 98,96,92,90,88,86 and 82%) as opposed to only 3/12(25%)patients (p<0.0001) in whom RE appeared during the second year of the follow up, at months 16,17,18 (respective percentages of patients without RE 80,78 and 76%). Conclusion: A substantial proportion of H.pylori successfully treated patients develop RE and the time trend suggests an increased risk during the first year after H.pylori eradication. Successful Helicobacter pylori (H.pylori) treatment has been reported to predispose to the development of reflux esophagitis (RE). However, despite this evidence, to date no attention had been paid to the time trend for the appearance of RE after H.pylori treatment. This information could be of importance in dealing with patient management after eradication. The aim of this prospective study therefore was two fold. Firstly, to examine the RE rate after H.pylori eradication and secondly, to study the time trend for the appearance of RE. Methods: 50 consecutive, successfully eradicated patients, without RE at the time of H.pylori treatment [25 duodenal ulcer (DU) and 25 non-ulcer (NU), 30M, 20F, median age 41.5 yrs, range 21-57] were followed up for 24 months after H.pylori eradication or when reflux symptoms occurred. The chi-square test for trend and the life table analysis were performed for calculating the incidence and time trend for RE appearance after H.pylori eradication. Patients were censored if the end point was reached or if RE was noted at endoscopy. Results: Among the 50 H.pylori(+) successfully treated patients, 12/50(24%) developed RE during the 24 month follow up period. In 9/12 patients(75%), RE developed during the first year of the follow up, at months 5,6,7,9,10,11 and 12 (respective percentages of patients without RE 98,96,92,90,88,86 and 82%) as opposed to only 3/12(25%)patients (p<0.0001) in whom RE appeared during the second year of the follow up, at months 16,17,18 (respective percentages of patients without RE 80,78 and 76%). Conclusion: A substantial proportion of H.pylori successfully treated patients develop RE and the time trend suggests an increased risk during the first year after H.pylori eradication." @default.
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• W1985845811 date "2000-04-01" @default.
• W1985845811 modified "2023-09-25" @default.
• W1985845811 title "3504 TIME TREND FOR THE APPEARANCE OF ESOPHAGITIS AFTER HELICOBACTER PYLORI ERADICATION." @default.
• W1985845811 doi "https://doi.org/10.1016/s0016-5107(00)14204-x" @default.
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