Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985852413> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1985852413 endingPage "901" @default.
- W1985852413 startingPage "898" @default.
- W1985852413 abstract "Borrelia miyamotoi, a relapsing fever spirochete transmitted by ixodid ticks, is able to cause infections associated with systemic complaints, including malaise and fever, as well as meningoencephalitis in immunocompromised patients. In order to elucidate immune evasion of previously difficult to cultivate B. miyamotoi, we have examined the ability of this newly emerging human pathogen to escape the complement system. Growth inhibition assays revealed that B. miyamotoi is strongly resistant to complement-mediated bacteriolysis. Investigating complement activation, we found that B. miyamotoi showed reduced deposition of components C3, C5, C7, C8, C9 as well as the membrane attack complex (MAC) on the borrelial surface. In addition, no aberrations in cell morphology were observed after incubation of B. miyamotoi in active human serum, confirming the findings of the growth inhibition assay. The data presented here provide strong evidence that B. miyamotoi overcome human complement by affecting the central complement component C3, thereby inhibiting formation of the C3 convertase and downstream activation of the complement cascade." @default.
- W1985852413 created "2016-06-24" @default.
- W1985852413 creator A5024773765 @default.
- W1985852413 creator A5036181854 @default.
- W1985852413 creator A5048614585 @default.
- W1985852413 creator A5048775979 @default.
- W1985852413 creator A5075799421 @default.
- W1985852413 date "2014-10-01" @default.
- W1985852413 modified "2023-09-24" @default.
- W1985852413 title "The relapsing fever spirochete Borrelia miyamotoi resists complement-mediated killing by human serum" @default.
- W1985852413 cites W1603513280 @default.
- W1985852413 cites W1669487765 @default.
- W1985852413 cites W1967977202 @default.
- W1985852413 cites W1971221639 @default.
- W1985852413 cites W1977332355 @default.
- W1985852413 cites W2008504899 @default.
- W1985852413 cites W2008799061 @default.
- W1985852413 cites W2030894706 @default.
- W1985852413 cites W2072401896 @default.
- W1985852413 cites W2089992715 @default.
- W1985852413 cites W2105595573 @default.
- W1985852413 cites W2115845050 @default.
- W1985852413 cites W2140448562 @default.
- W1985852413 cites W2140648680 @default.
- W1985852413 cites W2152200583 @default.
- W1985852413 cites W2157180378 @default.
- W1985852413 cites W2158191984 @default.
- W1985852413 cites W2161276511 @default.
- W1985852413 cites W2161382809 @default.
- W1985852413 doi "https://doi.org/10.1016/j.ttbdis.2014.07.011" @default.
- W1985852413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25104575" @default.
- W1985852413 hasPublicationYear "2014" @default.
- W1985852413 type Work @default.
- W1985852413 sameAs 1985852413 @default.
- W1985852413 citedByCount "14" @default.
- W1985852413 countsByYear W19858524132015 @default.
- W1985852413 countsByYear W19858524132016 @default.
- W1985852413 countsByYear W19858524132017 @default.
- W1985852413 countsByYear W19858524132018 @default.
- W1985852413 countsByYear W19858524132019 @default.
- W1985852413 countsByYear W19858524132020 @default.
- W1985852413 countsByYear W19858524132021 @default.
- W1985852413 countsByYear W19858524132022 @default.
- W1985852413 crossrefType "journal-article" @default.
- W1985852413 hasAuthorship W1985852413A5024773765 @default.
- W1985852413 hasAuthorship W1985852413A5036181854 @default.
- W1985852413 hasAuthorship W1985852413A5048614585 @default.
- W1985852413 hasAuthorship W1985852413A5048775979 @default.
- W1985852413 hasAuthorship W1985852413A5075799421 @default.
- W1985852413 hasConcept C111684460 @default.
- W1985852413 hasConcept C159047783 @default.
- W1985852413 hasConcept C159654299 @default.
- W1985852413 hasConcept C171279029 @default.
- W1985852413 hasConcept C189446657 @default.
- W1985852413 hasConcept C203014093 @default.
- W1985852413 hasConcept C2779159148 @default.
- W1985852413 hasConcept C2780508971 @default.
- W1985852413 hasConcept C2780977601 @default.
- W1985852413 hasConcept C2910311954 @default.
- W1985852413 hasConcept C86803240 @default.
- W1985852413 hasConcept C8891405 @default.
- W1985852413 hasConcept C89423630 @default.
- W1985852413 hasConcept C9478725 @default.
- W1985852413 hasConceptScore W1985852413C111684460 @default.
- W1985852413 hasConceptScore W1985852413C159047783 @default.
- W1985852413 hasConceptScore W1985852413C159654299 @default.
- W1985852413 hasConceptScore W1985852413C171279029 @default.
- W1985852413 hasConceptScore W1985852413C189446657 @default.
- W1985852413 hasConceptScore W1985852413C203014093 @default.
- W1985852413 hasConceptScore W1985852413C2779159148 @default.
- W1985852413 hasConceptScore W1985852413C2780508971 @default.
- W1985852413 hasConceptScore W1985852413C2780977601 @default.
- W1985852413 hasConceptScore W1985852413C2910311954 @default.
- W1985852413 hasConceptScore W1985852413C86803240 @default.
- W1985852413 hasConceptScore W1985852413C8891405 @default.
- W1985852413 hasConceptScore W1985852413C89423630 @default.
- W1985852413 hasConceptScore W1985852413C9478725 @default.
- W1985852413 hasIssue "6" @default.
- W1985852413 hasLocation W19858524131 @default.
- W1985852413 hasLocation W19858524132 @default.
- W1985852413 hasOpenAccess W1985852413 @default.
- W1985852413 hasPrimaryLocation W19858524131 @default.
- W1985852413 hasRelatedWork W1985852413 @default.
- W1985852413 hasRelatedWork W2030318870 @default.
- W1985852413 hasRelatedWork W2069490750 @default.
- W1985852413 hasRelatedWork W2152283040 @default.
- W1985852413 hasRelatedWork W2157728651 @default.
- W1985852413 hasRelatedWork W2462315822 @default.
- W1985852413 hasRelatedWork W2914087766 @default.
- W1985852413 hasRelatedWork W2980841281 @default.
- W1985852413 hasRelatedWork W4205741291 @default.
- W1985852413 hasRelatedWork W2946078457 @default.
- W1985852413 hasVolume "5" @default.
- W1985852413 isParatext "false" @default.
- W1985852413 isRetracted "false" @default.
- W1985852413 magId "1985852413" @default.
- W1985852413 workType "article" @default.