FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985857062> ?p ?o ?g. }

• W1985857062 endingPage "951" @default.
• W1985857062 startingPage "949" @default.
• W1985857062 abstract "Editor—Neural tube defects (NTDs) are among the most common and devastating birth defects. NTDs result from an incomplete closure of the neural tube, and include malformations of the skull, brain, meninges, spinal cord, and vertebral column. Recent evidence suggests that closure of the neural tube occurs in five separate sites which then fuse during the fourth week of gestation; NTDs occur when one site fails to close or two sites fail to fuse.1 During the last decade, periconceptional folic acid supplementation has been shown to reduce the risk of occurrence2 and recurrence3 of NTDs. Women with an NTD affected pregnancy do not usually have overt signs of folate deficiency, although decreased erythrocyte folate concentration, the index known to reflect whole body folate stores, has been reported.4 5 In addition, it has been reported that women with NTD pregnancies have raised homocysteine concentrations in plasma and amniotic fluid,6 7 suggesting that folate metabolism may be altered in these women.5,10-methylenetetrahydrofolate reductase (MTHFR) catalyses the reaction from 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, which serves as methyl donor for the remethylation of homocysteine to methionine.8 A substitution (C to T) at the highly conserved nucleotide 677 of the MTHFR gene has been described, which results in the conversion of an alanine (Ala) to a valine (Val) residue and increased in vitro thermolability of the enzyme.9 In vivo, the thermolabile MTHFR mutant is known to result in raised plasma homocysteine concentrations when folate nutriture is inadequate.10 The frequency of homozygosity for this mutation is approximately 9% for various populations, but is higher in French Canadian, Italian, and Hispanic populations, and lower in African-American populations.9 11-13 The C677T mutation has been reported to be a genetic risk factor for NTDs.11 14-17 However, the significance of …" @default.
• W1985857062 created "2016-06-24" @default.
• W1985857062 creator A5065302439 @default.
• W1985857062 date "2000-12-01" @default.
• W1985857062 modified "2023-10-16" @default.
• W1985857062 title "Comorbidity of 5,10-methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms and risk for neural tube defects" @default.
• W1985857062 cites W1608432708 @default.
• W1985857062 cites W1802058565 @default.
• W1985857062 cites W2001525363 @default.
• W1985857062 cites W2006833102 @default.
• W1985857062 cites W2012023230 @default.
• W1985857062 cites W2012049217 @default.
• W1985857062 cites W2017488615 @default.
• W1985857062 cites W2023172570 @default.
• W1985857062 cites W2031262735 @default.
• W1985857062 cites W2035815331 @default.
• W1985857062 cites W2036493913 @default.
• W1985857062 cites W2039569970 @default.
• W1985857062 cites W2046388121 @default.
• W1985857062 cites W2048151432 @default.
• W1985857062 cites W2051136548 @default.
• W1985857062 cites W2058241761 @default.
• W1985857062 cites W2077243611 @default.
• W1985857062 cites W2078410199 @default.
• W1985857062 cites W2079159618 @default.
• W1985857062 cites W2092730526 @default.
• W1985857062 cites W2114607509 @default.
• W1985857062 cites W2118311923 @default.
• W1985857062 cites W2122142898 @default.
• W1985857062 cites W2133886773 @default.
• W1985857062 cites W2139158679 @default.
• W1985857062 cites W2144062723 @default.
• W1985857062 cites W2160444453 @default.
• W1985857062 cites W2161314338 @default.
• W1985857062 cites W2165715420 @default.
• W1985857062 cites W2169155577 @default.
• W1985857062 cites W2234464918 @default.
• W1985857062 cites W2325417132 @default.
• W1985857062 cites W2412090825 @default.
• W1985857062 cites W2601068201 @default.
• W1985857062 cites W26321030 @default.
• W1985857062 doi "https://doi.org/10.1136/jmg.37.12.949" @default.
• W1985857062 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1734510" @default.
• W1985857062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11186937" @default.
• W1985857062 hasPublicationYear "2000" @default.
• W1985857062 type Work @default.
• W1985857062 sameAs 1985857062 @default.
• W1985857062 citedByCount "28" @default.
• W1985857062 countsByYear W19858570622012 @default.
• W1985857062 countsByYear W19858570622013 @default.
• W1985857062 countsByYear W19858570622014 @default.
• W1985857062 countsByYear W19858570622018 @default.
• W1985857062 countsByYear W19858570622022 @default.
• W1985857062 crossrefType "journal-article" @default.
• W1985857062 hasAuthorship W1985857062A5065302439 @default.
• W1985857062 hasBestOaLocation W19858570622 @default.
• W1985857062 hasConcept C104317684 @default.
• W1985857062 hasConcept C180754005 @default.
• W1985857062 hasConcept C196843134 @default.
• W1985857062 hasConcept C2780594696 @default.
• W1985857062 hasConcept C2780912031 @default.
• W1985857062 hasConcept C43563269 @default.
• W1985857062 hasConcept C515207424 @default.
• W1985857062 hasConcept C54355233 @default.
• W1985857062 hasConcept C60644358 @default.
• W1985857062 hasConcept C71924100 @default.
• W1985857062 hasConcept C80315684 @default.
• W1985857062 hasConcept C86803240 @default.
• W1985857062 hasConceptScore W1985857062C104317684 @default.
• W1985857062 hasConceptScore W1985857062C180754005 @default.
• W1985857062 hasConceptScore W1985857062C196843134 @default.
• W1985857062 hasConceptScore W1985857062C2780594696 @default.
• W1985857062 hasConceptScore W1985857062C2780912031 @default.
• W1985857062 hasConceptScore W1985857062C43563269 @default.
• W1985857062 hasConceptScore W1985857062C515207424 @default.
• W1985857062 hasConceptScore W1985857062C54355233 @default.
• W1985857062 hasConceptScore W1985857062C60644358 @default.
• W1985857062 hasConceptScore W1985857062C71924100 @default.
• W1985857062 hasConceptScore W1985857062C80315684 @default.
• W1985857062 hasConceptScore W1985857062C86803240 @default.
• W1985857062 hasIssue "12" @default.
• W1985857062 hasLocation W19858570621 @default.
• W1985857062 hasLocation W19858570622 @default.
• W1985857062 hasLocation W19858570623 @default.
• W1985857062 hasLocation W19858570624 @default.
• W1985857062 hasOpenAccess W1985857062 @default.
• W1985857062 hasPrimaryLocation W19858570621 @default.
• W1985857062 hasRelatedWork W2035362801 @default.
• W1985857062 hasRelatedWork W2058561140 @default.
• W1985857062 hasRelatedWork W2062816130 @default.
• W1985857062 hasRelatedWork W2087891957 @default.
• W1985857062 hasRelatedWork W2167039011 @default.
• W1985857062 hasRelatedWork W2359895783 @default.
• W1985857062 hasRelatedWork W2362805676 @default.
• W1985857062 hasRelatedWork W2595763102 @default.
• W1985857062 hasRelatedWork W2970347504 @default.
• W1985857062 hasRelatedWork W3158161280 @default.
• W1985857062 hasVolume "37" @default.

• next