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• W1985859801 abstract "In the present study, we investigated the anti-allergic activity of a glycoprotein isolated from Dioscorea batatas Decne (DBD glycoprotein, 30 kDa) on ovalbumin (OVA, 100 µg ml−1)-induced T helper (Th) type-2 response in primary cultured mouse lymphocytes. Our results revealed that the DBD glycoprotein (200 µg ml−1) significantly attenuated the expressions of interleukin (IL)-4 and IL-10, whereas enhanced the expression of interferon (IFN)-γ in OVA (100 µg ml−1)-treated primary cultured lymphocytes. We also found that the DBD glycoprotein has inhibitory effects on phosphorylations of signal transducer and activator of transcription (STAT)-6, p44/42 mitogen-activated protein kinase (MAPK) and p38 MAPK in primary cultured lymphocytes. Interestingly, the DBD glycoprotein suppressed the transcriptional activation of GATA-binding protein 3 (GATA-3), whereas it enhanced the activity of t-box expressed in T cells (T-bet) in OVA-stimulated lymphocytes. The results from these experiments indicated that the DBD glycoprotein inhibits expressions of IL-4 and IL-10 through modulation of GATA-3, STAT-6, p44/42 MAPK and p38 MAPK in mouse lymphocytes. Therefore, we speculated that the DBD glycoprotein might be one component for preparation of nutraceutical health supplements for prevention of Th2 cell response-related immune disorder. Copyright © 2009 John Wiley & Sons, Ltd." @default.
• W1985859801 created "2016-06-24" @default.
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• W1985859801 date "2009-07-01" @default.
• W1985859801 modified "2023-09-30" @default.
• W1985859801 title "Glycoprotein isolated from<i>Dioscorea batatas</i>Decne modulates expressions of IL-4 and IL-10 in primary-cultured mouse lymphocytes" @default.
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• W1985859801 doi "https://doi.org/10.1002/cbf.1577" @default.
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