FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985874150> ?p ?o ?g. }

• W1985874150 endingPage "e92342" @default.
• W1985874150 startingPage "e92342" @default.
• W1985874150 abstract "Both viral and host genetics affect the outcome of herpes simplex virus type 1 (HSV-1) infection in humans and experimental models. Little is known about specific host gene variants and molecular networks that influence herpetic disease progression, severity, and episodic reactivation. To identify such host gene variants we have initiated a forward genetic analysis using the expanded family of BXD strains, all derived from crosses between C57BL/6J and DBA/2J strains of mice. One parent is highly resistant and one highly susceptible to HSV-1. Both strains have also been fully sequenced, greatly facilitating the search for genetic modifiers that contribute to differences in HSV-1 infection. We monitored diverse disease phenotypes following infection with HSV-1 strain 17syn+ including percent mortality (herpes simplex encephalitis, HSE), body weight loss, severity of herpetic stromal keratitis (HSK), spleen weight, serum neutralizing antibody titers, and viral titers in tear films in BXD strains. A significant quantitative trait locus (QTL) on chromosome (Chr) 16 was found to associate with both percent mortality and HSK severity. Importantly, this QTL maps close to a human QTL and the gene proposed to be associated with the frequency of recurrent herpetic labialis (cold sores). This suggests that a single host locus may influence these seemingly diverse HSV-1 pathogenic phenotypes by as yet unknown mechanisms. Additional suggestive QTLs for percent mortality were identified—one on Chr X that is epistatically associated with that on Chr 16. As would be anticipated the Chr 16 QTL also modulated weight loss, reaching significance in females. A second significant QTL for maximum weight loss in male and female mice was mapped to Chr 12. To our knowledge this is the first report of a host genetic locus that modulates the severity of both herpetic disease in the nervous system and herpetic stromal keratitis." @default.
• W1985874150 created "2016-06-24" @default.
• W1985874150 creator A5000103692 @default.
• W1985874150 creator A5048851283 @default.
• W1985874150 creator A5079037023 @default.
• W1985874150 creator A5081260720 @default.
• W1985874150 date "2014-03-20" @default.
• W1985874150 modified "2023-09-24" @default.
• W1985874150 title "A Forward Phenotypically Driven Unbiased Genetic Analysis of Host Genes That Moderate Herpes Simplex Virus Virulence and Stromal Keratitis in Mice" @default.
• W1985874150 cites W1589473146 @default.
• W1985874150 cites W1898630910 @default.
• W1985874150 cites W1967616351 @default.
• W1985874150 cites W1969830421 @default.
• W1985874150 cites W1970754449 @default.
• W1985874150 cites W1975642253 @default.
• W1985874150 cites W1978317163 @default.
• W1985874150 cites W1988999154 @default.
• W1985874150 cites W1990205485 @default.
• W1985874150 cites W1990312994 @default.
• W1985874150 cites W1992677585 @default.
• W1985874150 cites W1999312866 @default.
• W1985874150 cites W2002262958 @default.
• W1985874150 cites W2004812763 @default.
• W1985874150 cites W2006266456 @default.
• W1985874150 cites W2009538412 @default.
• W1985874150 cites W2011916802 @default.
• W1985874150 cites W2015438051 @default.
• W1985874150 cites W2016333231 @default.
• W1985874150 cites W2017189695 @default.
• W1985874150 cites W2019846219 @default.
• W1985874150 cites W2024471864 @default.
• W1985874150 cites W2025425706 @default.
• W1985874150 cites W2026890958 @default.
• W1985874150 cites W2029088054 @default.
• W1985874150 cites W2034061614 @default.
• W1985874150 cites W2039914282 @default.
• W1985874150 cites W2041290903 @default.
• W1985874150 cites W2043786013 @default.
• W1985874150 cites W2043923971 @default.
• W1985874150 cites W2048626993 @default.
• W1985874150 cites W2054511824 @default.
• W1985874150 cites W2058071990 @default.
• W1985874150 cites W2064433163 @default.
• W1985874150 cites W2064452922 @default.
• W1985874150 cites W2068392302 @default.
• W1985874150 cites W2072819712 @default.
• W1985874150 cites W2073289420 @default.
• W1985874150 cites W2077484664 @default.
• W1985874150 cites W2085804098 @default.
• W1985874150 cites W2088910660 @default.
• W1985874150 cites W2097550991 @default.
• W1985874150 cites W2099624306 @default.
• W1985874150 cites W2100773500 @default.
• W1985874150 cites W2102504839 @default.
• W1985874150 cites W2108859569 @default.
• W1985874150 cites W2114316831 @default.
• W1985874150 cites W2119224914 @default.
• W1985874150 cites W2121672225 @default.
• W1985874150 cites W2127119928 @default.
• W1985874150 cites W2128587735 @default.
• W1985874150 cites W2131987313 @default.
• W1985874150 cites W2134321753 @default.
• W1985874150 cites W2138065975 @default.
• W1985874150 cites W2139651996 @default.
• W1985874150 cites W2144423642 @default.
• W1985874150 cites W2151074413 @default.
• W1985874150 cites W2151275811 @default.
• W1985874150 cites W2151802519 @default.
• W1985874150 cites W2153424741 @default.
• W1985874150 cites W2155784521 @default.
• W1985874150 cites W2160088199 @default.
• W1985874150 cites W2160353897 @default.
• W1985874150 cites W2161737006 @default.
• W1985874150 cites W2163219581 @default.
• W1985874150 cites W2168835213 @default.
• W1985874150 cites W2403187190 @default.
• W1985874150 cites W4238904365 @default.
• W1985874150 doi "https://doi.org/10.1371/journal.pone.0092342" @default.
• W1985874150 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3961320" @default.
• W1985874150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24651695" @default.
• W1985874150 hasPublicationYear "2014" @default.
• W1985874150 type Work @default.
• W1985874150 sameAs 1985874150 @default.
• W1985874150 citedByCount "17" @default.
• W1985874150 countsByYear W19858741502014 @default.
• W1985874150 countsByYear W19858741502015 @default.
• W1985874150 countsByYear W19858741502016 @default.
• W1985874150 countsByYear W19858741502019 @default.
• W1985874150 countsByYear W19858741502020 @default.
• W1985874150 countsByYear W19858741502022 @default.
• W1985874150 countsByYear W19858741502023 @default.
• W1985874150 crossrefType "journal-article" @default.
• W1985874150 hasAuthorship W1985874150A5000103692 @default.
• W1985874150 hasAuthorship W1985874150A5048851283 @default.
• W1985874150 hasAuthorship W1985874150A5079037023 @default.
• W1985874150 hasAuthorship W1985874150A5081260720 @default.
• W1985874150 hasBestOaLocation W19858741501 @default.
• W1985874150 hasConcept C104317684 @default.

• next