FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985874860> ?p ?o ?g. }

• W1985874860 endingPage "482" @default.
• W1985874860 startingPage "473" @default.
• W1985874860 abstract "Strict regulation of DNA replication is essential to ensure proper duplication and segregation of chromosomes during the cell cycle, as its deregulation can lead to genomic instability and cancer. Thus, eukaryotic organisms have evolved multiple mechanisms to restrict DNA replication to once per cell cycle. Here, we show that inactivation of Geminin, an inhibitor of origin licensing, leads to rereplication in human normal and tumor cells within the same cell cycle. We found a CHK1-dependent checkpoint to be activated in rereplicating cells accompanied by formation of gammaH2AX and RAD51 nuclear foci. Abrogation of the checkpoint leads to abortive mitosis and death of rereplicated cells. In addition, we demonstrate that the induction of rereplication is dependent on the replication initiation factors CDT1 and CDC6, and independent of the functional status of p53. These data show that Geminin is required for maintaining genomic stability in human cells." @default.
• W1985874860 created "2016-06-24" @default.
• W1985874860 creator A5011822969 @default.
• W1985874860 creator A5030828453 @default.
• W1985874860 creator A5033838080 @default.
• W1985874860 creator A5035498575 @default.
• W1985874860 creator A5060045790 @default.
• W1985874860 creator A5067368179 @default.
• W1985874860 creator A5067386157 @default.
• W1985874860 creator A5090729430 @default.
• W1985874860 date "2004-05-24" @default.
• W1985874860 modified "2023-10-11" @default.
• W1985874860 title "Loss of Geminin induces rereplication in the presence of functional p53" @default.
• W1985874860 cites W1546789359 @default.
• W1985874860 cites W1566625041 @default.
• W1985874860 cites W1752089945 @default.
• W1985874860 cites W1903850103 @default.
• W1985874860 cites W1978183360 @default.
• W1985874860 cites W1995667706 @default.
• W1985874860 cites W1997660869 @default.
• W1985874860 cites W2009905005 @default.
• W1985874860 cites W2010281502 @default.
• W1985874860 cites W2011206688 @default.
• W1985874860 cites W2016599680 @default.
• W1985874860 cites W2022893562 @default.
• W1985874860 cites W2027639574 @default.
• W1985874860 cites W2029304297 @default.
• W1985874860 cites W2029925140 @default.
• W1985874860 cites W2041254889 @default.
• W1985874860 cites W2043024617 @default.
• W1985874860 cites W2043895957 @default.
• W1985874860 cites W2045350461 @default.
• W1985874860 cites W2071919914 @default.
• W1985874860 cites W2072472133 @default.
• W1985874860 cites W2080125477 @default.
• W1985874860 cites W2081791597 @default.
• W1985874860 cites W2091038230 @default.
• W1985874860 cites W2106130068 @default.
• W1985874860 cites W2110803286 @default.
• W1985874860 cites W2110902629 @default.
• W1985874860 cites W2111772438 @default.
• W1985874860 cites W2125527622 @default.
• W1985874860 cites W2128056082 @default.
• W1985874860 cites W2130258750 @default.
• W1985874860 cites W2138533207 @default.
• W1985874860 cites W2146930996 @default.
• W1985874860 cites W2151180466 @default.
• W1985874860 cites W2153057184 @default.
• W1985874860 cites W2153574313 @default.
• W1985874860 cites W2154141161 @default.
• W1985874860 cites W2161340431 @default.
• W1985874860 cites W2163375855 @default.
• W1985874860 cites W2168225429 @default.
• W1985874860 cites W2400866665 @default.
• W1985874860 doi "https://doi.org/10.1083/jcb.200403106" @default.
• W1985874860 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2172361" @default.
• W1985874860 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15159417" @default.
• W1985874860 hasPublicationYear "2004" @default.
• W1985874860 type Work @default.
• W1985874860 sameAs 1985874860 @default.
• W1985874860 citedByCount "231" @default.
• W1985874860 countsByYear W19858748602012 @default.
• W1985874860 countsByYear W19858748602013 @default.
• W1985874860 countsByYear W19858748602014 @default.
• W1985874860 countsByYear W19858748602015 @default.
• W1985874860 countsByYear W19858748602016 @default.
• W1985874860 countsByYear W19858748602017 @default.
• W1985874860 countsByYear W19858748602018 @default.
• W1985874860 countsByYear W19858748602019 @default.
• W1985874860 countsByYear W19858748602020 @default.
• W1985874860 countsByYear W19858748602021 @default.
• W1985874860 countsByYear W19858748602022 @default.
• W1985874860 countsByYear W19858748602023 @default.
• W1985874860 crossrefType "journal-article" @default.
• W1985874860 hasAuthorship W1985874860A5011822969 @default.
• W1985874860 hasAuthorship W1985874860A5030828453 @default.
• W1985874860 hasAuthorship W1985874860A5033838080 @default.
• W1985874860 hasAuthorship W1985874860A5035498575 @default.
• W1985874860 hasAuthorship W1985874860A5060045790 @default.
• W1985874860 hasAuthorship W1985874860A5067368179 @default.
• W1985874860 hasAuthorship W1985874860A5067386157 @default.
• W1985874860 hasAuthorship W1985874860A5090729430 @default.
• W1985874860 hasBestOaLocation W19858748601 @default.
• W1985874860 hasConcept C104690221 @default.
• W1985874860 hasConcept C105696609 @default.
• W1985874860 hasConcept C143425029 @default.
• W1985874860 hasConcept C1491633281 @default.
• W1985874860 hasConcept C175193931 @default.
• W1985874860 hasConcept C178169997 @default.
• W1985874860 hasConcept C29537977 @default.
• W1985874860 hasConcept C41141232 @default.
• W1985874860 hasConcept C502942594 @default.
• W1985874860 hasConcept C54086632 @default.
• W1985874860 hasConcept C54355233 @default.
• W1985874860 hasConcept C552990157 @default.
• W1985874860 hasConcept C67419583 @default.
• W1985874860 hasConcept C73573662 @default.
• W1985874860 hasConcept C86803240 @default.

• next