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- W1985882425 abstract "Polymeric micelles have a whole set of unique characteristics, which make them very promising drug carriers, in particular, for poorly soluble drugs. Our review article focuses on micelles prepared from conjugates of water-soluble polymers, such as polyethylene glycol (PEG) or polyvinyl pyrrolidone (PVP), with phospholipids or long-chain fatty acids. The preparation of micelles from certain polymer-lipid conjugates and the loading of these micelles with various poorly soluble anticancer agents are discussed. The data on the characterization of micellar preparations in terms of their morphology, stability, longevity in circulation, and ability to spontaneously accumulate in experimental tumors via the enhanced permeability and retention (EPR) effect are presented. The review also considers the preparation of targeted immunomicelles with specific antibodies attached to their surface. Available in vivo results on the efficiency of anticancer drugs incorporated into plain micelles and immunomicelles in animal models are also discussed." @default.
- W1985882425 created "2016-06-24" @default.
- W1985882425 creator A5031677550 @default.
- W1985882425 creator A5084391530 @default.
- W1985882425 date "2004-05-01" @default.
- W1985882425 modified "2023-10-14" @default.
- W1985882425 title "Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs" @default.
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- W1985882425 doi "https://doi.org/10.1016/j.addr.2003.12.004" @default.
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