Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985889388> ?p ?o ?g. }
- W1985889388 endingPage "3008" @default.
- W1985889388 startingPage "3001" @default.
- W1985889388 abstract "The epidermal growth factor (EGF) is a member of the growth factor superfamily that can stimulate the proliferation of many types of cells. Overexpression of EGF receptor (EGFR) was observed in many types of cancer cells. Anti-EGFR antibodies or antisense nucleic acid sequences of EGFR can suppress the growth of hepatoma cells. In order to further investigate the proteome alterations associated with malignant growth of the human hepatoma cells and the influence of EGFR signal pathway on the cellular proteome, we have comparatively analyzed the proteomes of human hepatoma cells transfected with antisense EGFR sequence (cell strain JX-1) and its control cells (cell strain JX-0) by two-dimensional (2-D) gel electrophoresis and mass spectrometry. Image analysis of silver-stained 2-D gels revealed that 40 protein spots showed significant expression changes in JX-1 cells compared to JX-0 cells. Three of them, including the tumor suppressor protein maspin, changed with tendency to the normal levels. Two protein spots were identified as HSP27 in the same gel, and one of them had a reduced level in JX-1 cells. The apparent alterations of HSP27 in expression level might be the results from their differential chemical modifications, suggesting the effect of dynamic post-translational modifications of proteins on the growth of hepatoma cells. Other proteins such as glutathione peroxidase (GPX-1) and 14-3-3-sigma also exhibited altered expression in JX-1 cells, and their functional implications are discussed." @default.
- W1985889388 created "2016-06-24" @default.
- W1985889388 creator A5001853771 @default.
- W1985889388 creator A5028708493 @default.
- W1985889388 creator A5035790561 @default.
- W1985889388 creator A5054168686 @default.
- W1985889388 creator A5061793338 @default.
- W1985889388 creator A5074407139 @default.
- W1985889388 creator A5080232976 @default.
- W1985889388 date "2001-08-01" @default.
- W1985889388 modified "2023-10-17" @default.
- W1985889388 title "Proteome alterations in human hepatoma cells transfected with antisense epidermal growth factor receptor sequence" @default.
- W1985889388 cites W1484893220 @default.
- W1985889388 cites W1502713173 @default.
- W1985889388 cites W1550351158 @default.
- W1985889388 cites W1606423922 @default.
- W1985889388 cites W1964632987 @default.
- W1985889388 cites W1965568245 @default.
- W1985889388 cites W1967099091 @default.
- W1985889388 cites W1967712096 @default.
- W1985889388 cites W1973708209 @default.
- W1985889388 cites W1988556197 @default.
- W1985889388 cites W1995382459 @default.
- W1985889388 cites W1996683778 @default.
- W1985889388 cites W2000225365 @default.
- W1985889388 cites W2002294272 @default.
- W1985889388 cites W2003925684 @default.
- W1985889388 cites W2008390946 @default.
- W1985889388 cites W2013596633 @default.
- W1985889388 cites W2016441400 @default.
- W1985889388 cites W2016568386 @default.
- W1985889388 cites W2026465178 @default.
- W1985889388 cites W2037217230 @default.
- W1985889388 cites W2038119361 @default.
- W1985889388 cites W2046176730 @default.
- W1985889388 cites W2048263097 @default.
- W1985889388 cites W2056437543 @default.
- W1985889388 cites W2081591939 @default.
- W1985889388 cites W2086652886 @default.
- W1985889388 cites W2086794486 @default.
- W1985889388 cites W2089055216 @default.
- W1985889388 cites W2146447599 @default.
- W1985889388 cites W2150011315 @default.
- W1985889388 cites W2152319713 @default.
- W1985889388 cites W2160073719 @default.
- W1985889388 cites W2165286534 @default.
- W1985889388 cites W2912078763 @default.
- W1985889388 cites W4231741351 @default.
- W1985889388 cites W4244120980 @default.
- W1985889388 cites W4253517795 @default.
- W1985889388 doi "https://doi.org/10.1002/1522-2683(200108)22:14<3001::aid-elps3001>3.0.co;2-5" @default.
- W1985889388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11565794" @default.
- W1985889388 hasPublicationYear "2001" @default.
- W1985889388 type Work @default.
- W1985889388 sameAs 1985889388 @default.
- W1985889388 citedByCount "21" @default.
- W1985889388 countsByYear W19858893882012 @default.
- W1985889388 crossrefType "journal-article" @default.
- W1985889388 hasAuthorship W1985889388A5001853771 @default.
- W1985889388 hasAuthorship W1985889388A5028708493 @default.
- W1985889388 hasAuthorship W1985889388A5035790561 @default.
- W1985889388 hasAuthorship W1985889388A5054168686 @default.
- W1985889388 hasAuthorship W1985889388A5061793338 @default.
- W1985889388 hasAuthorship W1985889388A5074407139 @default.
- W1985889388 hasAuthorship W1985889388A5080232976 @default.
- W1985889388 hasConcept C104397665 @default.
- W1985889388 hasConcept C121608353 @default.
- W1985889388 hasConcept C153911025 @default.
- W1985889388 hasConcept C170493617 @default.
- W1985889388 hasConcept C26375932 @default.
- W1985889388 hasConcept C2775960820 @default.
- W1985889388 hasConcept C2776362946 @default.
- W1985889388 hasConcept C2779438470 @default.
- W1985889388 hasConcept C54009773 @default.
- W1985889388 hasConcept C54355233 @default.
- W1985889388 hasConcept C55493867 @default.
- W1985889388 hasConcept C62112901 @default.
- W1985889388 hasConcept C62478195 @default.
- W1985889388 hasConcept C81885089 @default.
- W1985889388 hasConcept C86803240 @default.
- W1985889388 hasConcept C95444343 @default.
- W1985889388 hasConcept C96232424 @default.
- W1985889388 hasConceptScore W1985889388C104397665 @default.
- W1985889388 hasConceptScore W1985889388C121608353 @default.
- W1985889388 hasConceptScore W1985889388C153911025 @default.
- W1985889388 hasConceptScore W1985889388C170493617 @default.
- W1985889388 hasConceptScore W1985889388C26375932 @default.
- W1985889388 hasConceptScore W1985889388C2775960820 @default.
- W1985889388 hasConceptScore W1985889388C2776362946 @default.
- W1985889388 hasConceptScore W1985889388C2779438470 @default.
- W1985889388 hasConceptScore W1985889388C54009773 @default.
- W1985889388 hasConceptScore W1985889388C54355233 @default.
- W1985889388 hasConceptScore W1985889388C55493867 @default.
- W1985889388 hasConceptScore W1985889388C62112901 @default.
- W1985889388 hasConceptScore W1985889388C62478195 @default.
- W1985889388 hasConceptScore W1985889388C81885089 @default.
- W1985889388 hasConceptScore W1985889388C86803240 @default.
- W1985889388 hasConceptScore W1985889388C95444343 @default.