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• W1985890209 abstract "In vivo metabolism and depuration of benzo [a]pyrene (BaP) was studied in the blue mussel Mytilus edulis. In one experiment, the animals were injected with 3H-BaP and thereafter exposed to either a high (H) or a low (L) concentration of the alga Isochrysis galbana. Mussels were sampled after 2, 4, 8, 16, and 32 d and temporal changes in the metabolite profiles were analyzed using nonpolar and polar solvents. The metabolic fate and the depuration rate of BaP from the two feeding groups were compared. In a second experiment, mussels were exposed to [3H]-BaP or [14C]-BaP either injected or via the surrounding water, and the tissue distribution of radiolabeled compound was studied. The half-life of BaP was 15–17 days and unaffected by the food concentration. The metabolic profile differed slightly between the two treatments. Animals in the L group had a significant peak in the quantity of macromolecular adducts eight days after the injection, whereas the H group had a fairly stable amount of adducts throughout the experimental period. The tissue distribution study revealed that the radiolabeled compound was mainly present in the epithelial cells of the hepatopancreas and the ciliated epithelial cells of the gills. A fraction of the radioactivity was firmly bound." @default.
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• W1985890209 date "2000-11-01" @default.
• W1985890209 modified "2023-09-27" @default.
• W1985890209 title "Tissue disposition of benzo[A]pyrene in blue mussel (Mytilus edulis) and effect of algal concentration on metabolism and depuration" @default.
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• W1985890209 doi "https://doi.org/10.1002/etc.5620191111" @default.
• W1985890209 hasPublicationYear "2000" @default.
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