FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985902016> ?p ?o ?g. }

• W1985902016 endingPage "1882" @default.
• W1985902016 startingPage "1878" @default.
• W1985902016 abstract "A new cancer gene, HIC-1 (Hypermethylated in Cancer) telomeric to p53 on chromosome 17p may be of clinical importance in sporadic breast cancer. Regional DNA hypermethylation of 17p13.3 resulting in suppression of gene expression has been shown to precede 17p structural changes in human carcinogenesis. In addition, loss of heterozygosity studies have suggested clinically significant involvement of a gene on 17p13.3 associated with poor prognosis in breast cancer. Using RT-PCR analysis, we demonstrate that the MCF7 (wild type p53) cell line expressed HIC-1 transcripts but the MDAMB231 (mutant p53) cell line did not, suggesting loss of HIC-1 expression and p53 malfunction may be synergistic events in sporadic breast cancer. HIC-1 expression was examined using RT-PCR on RNA extracted from 50 primary untreated, human breast cancers and was detected in only 7/50 (14%) cancers. All seven patients with HIC-1 expression were alive without disease recurrence after 8 years follow-up and 5/7 had detectable p53 wild type mRNA expression. This suggests that retained HIC-1 expression may offer a survival advantage. However the seven cancers had 17p13.3 loss of heterozygosity (LOH; four patients), a feature previously associated with poor prognosis, or were homozygous (three patients) suggesting there may be two genes at 17p13.3 involved in breast carcinogenesis. Using a demethylating drug 5-aza-2′-deoxycytidine (DeoxyC), HIC-1 expression was restored in the MDAMB231 cells, also suggesting restoration of HIC-1 function by reversing HIC-1 hypermethylation may offer a therapeutic avenue in breast cancer. © 2001 Cancer Research Campaign http://www.bjcancer.com" @default.
• W1985902016 created "2016-06-24" @default.
• W1985902016 creator A5008153863 @default.
• W1985902016 creator A5027846283 @default.
• W1985902016 creator A5041233438 @default.
• W1985902016 creator A5055443704 @default.
• W1985902016 creator A5082767643 @default.
• W1985902016 creator A5085196093 @default.
• W1985902016 date "2001-12-01" @default.
• W1985902016 modified "2023-10-06" @default.
• W1985902016 title "Expression of the hypermethylated in cancer gene (HIC-1) is associated with good outcome in human breast cancer" @default.
• W1985902016 cites W1507752168 @default.
• W1985902016 cites W1517954917 @default.
• W1985902016 cites W1834519193 @default.
• W1985902016 cites W1966971933 @default.
• W1985902016 cites W1975223632 @default.
• W1985902016 cites W1976360812 @default.
• W1985902016 cites W1990120418 @default.
• W1985902016 cites W1998885383 @default.
• W1985902016 cites W2017427575 @default.
• W1985902016 cites W2019432938 @default.
• W1985902016 cites W2048226408 @default.
• W1985902016 cites W2055150942 @default.
• W1985902016 cites W2077883966 @default.
• W1985902016 cites W2079893891 @default.
• W1985902016 cites W2088052909 @default.
• W1985902016 cites W2090701958 @default.
• W1985902016 cites W2105886105 @default.
• W1985902016 cites W2115743878 @default.
• W1985902016 cites W2119798255 @default.
• W1985902016 cites W2124181024 @default.
• W1985902016 cites W2126809688 @default.
• W1985902016 cites W2131922441 @default.
• W1985902016 cites W2161967149 @default.
• W1985902016 cites W2412410165 @default.
• W1985902016 cites W2077622651 @default.
• W1985902016 doi "https://doi.org/10.1054/bjoc.2001.2163" @default.
• W1985902016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2363999" @default.
• W1985902016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11747329" @default.
• W1985902016 hasPublicationYear "2001" @default.
• W1985902016 type Work @default.
• W1985902016 sameAs 1985902016 @default.
• W1985902016 citedByCount "39" @default.
• W1985902016 countsByYear W19859020162012 @default.
• W1985902016 countsByYear W19859020162013 @default.
• W1985902016 countsByYear W19859020162014 @default.
• W1985902016 countsByYear W19859020162015 @default.
• W1985902016 countsByYear W19859020162016 @default.
• W1985902016 countsByYear W19859020162018 @default.
• W1985902016 countsByYear W19859020162020 @default.
• W1985902016 crossrefType "journal-article" @default.
• W1985902016 hasAuthorship W1985902016A5008153863 @default.
• W1985902016 hasAuthorship W1985902016A5027846283 @default.
• W1985902016 hasAuthorship W1985902016A5041233438 @default.
• W1985902016 hasAuthorship W1985902016A5055443704 @default.
• W1985902016 hasAuthorship W1985902016A5082767643 @default.
• W1985902016 hasAuthorship W1985902016A5085196093 @default.
• W1985902016 hasBestOaLocation W19859020161 @default.
• W1985902016 hasConcept C104317684 @default.
• W1985902016 hasConcept C121608353 @default.
• W1985902016 hasConcept C126322002 @default.
• W1985902016 hasConcept C142724271 @default.
• W1985902016 hasConcept C143589142 @default.
• W1985902016 hasConcept C143998085 @default.
• W1985902016 hasConcept C150194340 @default.
• W1985902016 hasConcept C180754005 @default.
• W1985902016 hasConcept C190727270 @default.
• W1985902016 hasConcept C2778264664 @default.
• W1985902016 hasConcept C502942594 @default.
• W1985902016 hasConcept C530470458 @default.
• W1985902016 hasConcept C54355233 @default.
• W1985902016 hasConcept C555283112 @default.
• W1985902016 hasConcept C71924100 @default.
• W1985902016 hasConcept C86803240 @default.
• W1985902016 hasConceptScore W1985902016C104317684 @default.
• W1985902016 hasConceptScore W1985902016C121608353 @default.
• W1985902016 hasConceptScore W1985902016C126322002 @default.
• W1985902016 hasConceptScore W1985902016C142724271 @default.
• W1985902016 hasConceptScore W1985902016C143589142 @default.
• W1985902016 hasConceptScore W1985902016C143998085 @default.
• W1985902016 hasConceptScore W1985902016C150194340 @default.
• W1985902016 hasConceptScore W1985902016C180754005 @default.
• W1985902016 hasConceptScore W1985902016C190727270 @default.
• W1985902016 hasConceptScore W1985902016C2778264664 @default.
• W1985902016 hasConceptScore W1985902016C502942594 @default.
• W1985902016 hasConceptScore W1985902016C530470458 @default.
• W1985902016 hasConceptScore W1985902016C54355233 @default.
• W1985902016 hasConceptScore W1985902016C555283112 @default.
• W1985902016 hasConceptScore W1985902016C71924100 @default.
• W1985902016 hasConceptScore W1985902016C86803240 @default.
• W1985902016 hasIssue "12" @default.
• W1985902016 hasLocation W19859020161 @default.
• W1985902016 hasLocation W19859020162 @default.
• W1985902016 hasLocation W19859020163 @default.
• W1985902016 hasLocation W19859020164 @default.
• W1985902016 hasLocation W19859020165 @default.
• W1985902016 hasOpenAccess W1985902016 @default.
• W1985902016 hasPrimaryLocation W19859020161 @default.

• next