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- W1985918585 abstract "The generalized structural transitions of erythrocyte membranes induced by cyclic AMP were registered by ESR, fluorescence, freeze-fracture and circular dichroism methods. Two transitions different in nature were revealed. One, which arises at 10-(11)--10-(10) M cyclic AMP, is cooperative and may be considered as a consequence of interaction of cyclic AMP with a receptor. It was calculated that a structural rearrangement in one erythrocyte ghost is induced by three cyclic AMP molecules. As a result of it the membranes are loosened. The other transition arises at 10-(10)--10-(8) M cyclic AMP and depends on the activity of the protein kinase system. This transition was shown to be non-cooperative and due to phosphorylation of membranous proteins. During this rearrangement the membranes are stiffened. Both transitions were demonstrated to relate to the membrane integrity." @default.
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- W1985918585 date "1977-10-01" @default.
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- W1985918585 title "The structural transitions of erythrocyte membranes induced by cyclic AMP" @default.
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- W1985918585 doi "https://doi.org/10.1016/0005-2736(77)90102-x" @default.
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