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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985921753> ?p ?o ?g. }

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• W1985921753 abstract "Novel nonpeptide small molecule renin inhibitors bearing an N-isopropyl P(1) motif were designed based on initial lead structures 1 and aliskiren (2). (P(3)-P(1))-Benzamide derivatives such as 9a and 34, as well as the corresponding P(1) basic tertiary amine derivatives 10 and 35 were found to display low nanomolar inhibition against human renin in vitro." @default.
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• W1985921753 date "2009-08-01" @default.
• W1985921753 modified "2023-09-23" @default.
• W1985921753 title "The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin" @default.
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• W1985921753 doi "https://doi.org/10.1016/j.bmcl.2009.05.128" @default.
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