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• W1985922024 endingPage "C850" @default.
• W1985922024 startingPage "C844" @default.
• W1985922024 abstract "The plasma membrane Na(+)/H(+) exchanger NHE1 has an established function in intracellular pH and cell volume homeostasis by catalyzing electroneutral influx of extracellular Na(+) and efflux of intracellular H(+). A second function of NHE1 as a structural anchor for actin filaments through its direct binding of the ezrin, radixin, and moesin (ERM) family of actin-binding proteins was recently identified. ERM protein binding and actin anchoring by NHE1 are necessary to retain the localization of NHE1 in specialized plasma membrane domains and to promote cytoskeleton-dependent processes, including actin filament bundling and cell-substrate adhesions. This review explores a third function of NHE1, as a plasma membrane scaffold in the assembly of signaling complexes. Through its coordinate functions in H(+) efflux, actin anchoring, and scaffolding, we propose that NHE1 promotes protein interactions and activities, assembles signaling complexes in specialized plasma membrane domains, and coordinates divergent signaling pathways." @default.
• W1985922024 created "2016-06-24" @default.
• W1985922024 creator A5018995226 @default.
• W1985922024 creator A5042219792 @default.
• W1985922024 creator A5081183919 @default.
• W1985922024 date "2004-10-01" @default.
• W1985922024 modified "2023-09-23" @default.
• W1985922024 title "Na⁺/H⁺exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes" @default.
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• W1985922024 doi "https://doi.org/10.1152/ajpcell.00094.2004" @default.
• W1985922024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15355855" @default.
• W1985922024 hasPublicationYear "2004" @default.
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