FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985929283> ?p ?o ?g. }

• W1985929283 endingPage "472" @default.
• W1985929283 startingPage "465" @default.
• W1985929283 abstract "Niemann-Pick type C (NPC) disease is a neuro-visceral cholesterol storage disorder caused by mutations in the NPC-1 or NPC-2 gene. In the present paper, we studied IR (insulin receptor) activation and the plasma-membrane lipid assembly in primary hepatocytes from control and NPC1-/- mice. We have previously reported that, in hepatocytes, IR activation is dependent on cholesterol-sphingolipid rafts [Vainio, Heino, Mansson, Fredman, Kuismanen, Vaarala and Ikonen (2002) EMBO Rep. 3, 95-100]. We found that, in NPC hepatocytes, IR levels were up-regulated and the receptor activation was compromised. Defective IR activation was reproduced in isolated NPC plasma-membrane preparations, which displayed an increased cholesterol content and saturation of major phospholipids. The NPC plasma membranes were less fluid than control membranes as indicated by increased DPH (1,6-diphenyl-1,3,5-hexatriene) fluorescence anisotropy values. Both in NPC hepatocytes and plasma-membrane fractions, the association of IR with low-density DRMs (detergent-resistant membranes) was increased. Moreover, the detergent resistance of both cholesterol and phosphatidylcholine were increased in NPC membranes. Finally, cholesterol removal inhibited IR activation in control membranes but restored IR activation in NPC membranes. Taken together, the results reveal a lipid imbalance in the NPC hepatocyte, which increases lipid ordering in the plasma membrane, alters the properties of lipid rafts and interferes with the function of a raft-associated plasma-membrane receptor. Such a mechanism may participate in the pathogenesis of NPC disease and contribute to insulin resistance in other disorders of lipid metabolism." @default.
• W1985929283 created "2016-06-24" @default.
• W1985929283 creator A5007270321 @default.
• W1985929283 creator A5007694122 @default.
• W1985929283 creator A5039498150 @default.
• W1985929283 creator A5046149079 @default.
• W1985929283 creator A5068795367 @default.
• W1985929283 creator A5083926509 @default.
• W1985929283 date "2005-10-25" @default.
• W1985929283 modified "2023-10-06" @default.
• W1985929283 title "Defective insulin receptor activation and altered lipid rafts in Niemann–Pick type C disease hepatocytes" @default.
• W1985929283 cites W1536231102 @default.
• W1985929283 cites W1564861448 @default.
• W1985929283 cites W1572009433 @default.
• W1985929283 cites W1573704377 @default.
• W1985929283 cites W1588205455 @default.
• W1985929283 cites W1605681980 @default.
• W1985929283 cites W1791271593 @default.
• W1985929283 cites W1822687991 @default.
• W1985929283 cites W1940329105 @default.
• W1985929283 cites W1969699638 @default.
• W1985929283 cites W1983606596 @default.
• W1985929283 cites W1995873562 @default.
• W1985929283 cites W2001759749 @default.
• W1985929283 cites W2012008185 @default.
• W1985929283 cites W2014887370 @default.
• W1985929283 cites W2017088069 @default.
• W1985929283 cites W2026747629 @default.
• W1985929283 cites W2037821728 @default.
• W1985929283 cites W2041205811 @default.
• W1985929283 cites W2056194352 @default.
• W1985929283 cites W2060868781 @default.
• W1985929283 cites W2061334464 @default.
• W1985929283 cites W2061685989 @default.
• W1985929283 cites W2068994489 @default.
• W1985929283 cites W2072024204 @default.
• W1985929283 cites W2076246718 @default.
• W1985929283 cites W2080259994 @default.
• W1985929283 cites W2084930289 @default.
• W1985929283 cites W2088139733 @default.
• W1985929283 cites W2092296126 @default.
• W1985929283 cites W2093395392 @default.
• W1985929283 cites W2096439143 @default.
• W1985929283 cites W2096864428 @default.
• W1985929283 cites W2100904923 @default.
• W1985929283 cites W2102736268 @default.
• W1985929283 cites W2121936687 @default.
• W1985929283 cites W2139608294 @default.
• W1985929283 cites W2156128416 @default.
• W1985929283 cites W2159988116 @default.
• W1985929283 cites W2160085864 @default.
• W1985929283 cites W2164578997 @default.
• W1985929283 cites W2168016965 @default.
• W1985929283 cites W2168526937 @default.
• W1985929283 cites W2170461853 @default.
• W1985929283 cites W2186094021 @default.
• W1985929283 cites W2325770196 @default.
• W1985929283 cites W2404921941 @default.
• W1985929283 cites W2411204330 @default.
• W1985929283 doi "https://doi.org/10.1042/bj20050460" @default.
• W1985929283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1276947" @default.
• W1985929283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15943586" @default.
• W1985929283 hasPublicationYear "2005" @default.
• W1985929283 type Work @default.
• W1985929283 sameAs 1985929283 @default.
• W1985929283 citedByCount "65" @default.
• W1985929283 countsByYear W19859292832012 @default.
• W1985929283 countsByYear W19859292832013 @default.
• W1985929283 countsByYear W19859292832014 @default.
• W1985929283 countsByYear W19859292832015 @default.
• W1985929283 countsByYear W19859292832016 @default.
• W1985929283 countsByYear W19859292832017 @default.
• W1985929283 countsByYear W19859292832018 @default.
• W1985929283 countsByYear W19859292832019 @default.
• W1985929283 countsByYear W19859292832020 @default.
• W1985929283 countsByYear W19859292832021 @default.
• W1985929283 countsByYear W19859292832023 @default.
• W1985929283 crossrefType "journal-article" @default.
• W1985929283 hasAuthorship W1985929283A5007270321 @default.
• W1985929283 hasAuthorship W1985929283A5007694122 @default.
• W1985929283 hasAuthorship W1985929283A5039498150 @default.
• W1985929283 hasAuthorship W1985929283A5046149079 @default.
• W1985929283 hasAuthorship W1985929283A5068795367 @default.
• W1985929283 hasAuthorship W1985929283A5083926509 @default.
• W1985929283 hasBestOaLocation W19859292832 @default.
• W1985929283 hasConcept C102747710 @default.
• W1985929283 hasConcept C126322002 @default.
• W1985929283 hasConcept C134018914 @default.
• W1985929283 hasConcept C170493617 @default.
• W1985929283 hasConcept C185592680 @default.
• W1985929283 hasConcept C202751555 @default.
• W1985929283 hasConcept C2776200302 @default.
• W1985929283 hasConcept C2777391703 @default.
• W1985929283 hasConcept C2778163477 @default.
• W1985929283 hasConcept C2778552423 @default.
• W1985929283 hasConcept C2779306644 @default.
• W1985929283 hasConcept C41625074 @default.
• W1985929283 hasConcept C55493867 @default.

• next