FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985940575> ?p ?o ?g. }

• W1985940575 endingPage "106" @default.
• W1985940575 startingPage "99" @default.
• W1985940575 abstract "The present study evaluated dynamic coagulation profiles, platelet aggregation, and thrombin generation in whole blood (WB) from eight children with thrombocytopenia during chemotherapy, and the haemostatic potential of platelets (+60 x 10(9)/l), recombinant factor VIIa (rFVIIa - NovoSeven), and a potent rFVIIa analogue (NN1731) both at 1 and 4 microg/ml. Dynamic WB coagulation profiles were recorded by thrombelastometry employing activation with tissue factor (TF - Innovin) at low concentrations. The baseline WB coagulation patterns were characterised by a prolonged clotting time (CT) and a pronounced reduction in clot propagation (MaxVel). WB platelet aggregation signal was five times lower in the study group compared with measurements in modelled thrombocytopenic WB from healthy volunteers. In vitro addition of fresh platelets reversed the coagulopathy. Addition of rFVIIa induced no significant changes in the thrombelastographic profile, whereas spiking with NN1731 shortened the CT significantly. The changes in WB thrombin generation reflected the changes in the MaxVel. In modeled thrombocytopenic WB from healthy individuals, both rFVIIa and NN1731 exhibited a pronounced haemostatic effect with NN1731 showing greater potency than rFVIIa. Compromised platelet function in the study group was assumingly responsible for the weakened haemostatic potential of rFVIIa as well as that of NN1731." @default.
• W1985940575 created "2016-06-24" @default.
• W1985940575 creator A5004228898 @default.
• W1985940575 creator A5032700341 @default.
• W1985940575 creator A5041774798 @default.
• W1985940575 creator A5066208623 @default.
• W1985940575 creator A5075239871 @default.
• W1985940575 creator A5081018170 @default.
• W1985940575 date "2008-12-09" @default.
• W1985940575 modified "2023-10-13" @default.
• W1985940575 title "Whole blood coagulation in children with thrombocytopenia and the response to platelet replacement, recombinant factor VIIa, and a potent factor VIIa analogue" @default.
• W1985940575 cites W1963569702 @default.
• W1985940575 cites W1964715859 @default.
• W1985940575 cites W1965695013 @default.
• W1985940575 cites W1970976986 @default.
• W1985940575 cites W1977689290 @default.
• W1985940575 cites W1991130709 @default.
• W1985940575 cites W1994393898 @default.
• W1985940575 cites W2008282611 @default.
• W1985940575 cites W2018784308 @default.
• W1985940575 cites W2031320632 @default.
• W1985940575 cites W2032964119 @default.
• W1985940575 cites W2036185700 @default.
• W1985940575 cites W2037652834 @default.
• W1985940575 cites W2038005163 @default.
• W1985940575 cites W2053652650 @default.
• W1985940575 cites W2058191799 @default.
• W1985940575 cites W2070158670 @default.
• W1985940575 cites W2075429091 @default.
• W1985940575 cites W2085599612 @default.
• W1985940575 cites W2095631860 @default.
• W1985940575 cites W2099079542 @default.
• W1985940575 cites W2127414127 @default.
• W1985940575 cites W2129609495 @default.
• W1985940575 cites W2145399350 @default.
• W1985940575 cites W2158818146 @default.
• W1985940575 cites W2160784005 @default.
• W1985940575 cites W2164194915 @default.
• W1985940575 cites W2295465622 @default.
• W1985940575 cites W4245219249 @default.
• W1985940575 doi "https://doi.org/10.1111/j.1365-2141.2008.07439.x" @default.
• W1985940575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19016728" @default.
• W1985940575 hasPublicationYear "2008" @default.
• W1985940575 type Work @default.
• W1985940575 sameAs 1985940575 @default.
• W1985940575 citedByCount "15" @default.
• W1985940575 countsByYear W19859405752012 @default.
• W1985940575 countsByYear W19859405752013 @default.
• W1985940575 countsByYear W19859405752014 @default.
• W1985940575 countsByYear W19859405752015 @default.
• W1985940575 countsByYear W19859405752017 @default.
• W1985940575 countsByYear W19859405752018 @default.
• W1985940575 crossrefType "journal-article" @default.
• W1985940575 hasAuthorship W1985940575A5004228898 @default.
• W1985940575 hasAuthorship W1985940575A5032700341 @default.
• W1985940575 hasAuthorship W1985940575A5041774798 @default.
• W1985940575 hasAuthorship W1985940575A5066208623 @default.
• W1985940575 hasAuthorship W1985940575A5075239871 @default.
• W1985940575 hasAuthorship W1985940575A5081018170 @default.
• W1985940575 hasBestOaLocation W19859405751 @default.
• W1985940575 hasConcept C126322002 @default.
• W1985940575 hasConcept C1621761 @default.
• W1985940575 hasConcept C186738567 @default.
• W1985940575 hasConcept C203014093 @default.
• W1985940575 hasConcept C2777292125 @default.
• W1985940575 hasConcept C2777664302 @default.
• W1985940575 hasConcept C2778382381 @default.
• W1985940575 hasConcept C2778589496 @default.
• W1985940575 hasConcept C2778961111 @default.
• W1985940575 hasConcept C2779936836 @default.
• W1985940575 hasConcept C2780930249 @default.
• W1985940575 hasConcept C2910686401 @default.
• W1985940575 hasConcept C42219234 @default.
• W1985940575 hasConcept C71924100 @default.
• W1985940575 hasConcept C77171857 @default.
• W1985940575 hasConcept C89560881 @default.
• W1985940575 hasConcept C98274493 @default.
• W1985940575 hasConceptScore W1985940575C126322002 @default.
• W1985940575 hasConceptScore W1985940575C1621761 @default.
• W1985940575 hasConceptScore W1985940575C186738567 @default.
• W1985940575 hasConceptScore W1985940575C203014093 @default.
• W1985940575 hasConceptScore W1985940575C2777292125 @default.
• W1985940575 hasConceptScore W1985940575C2777664302 @default.
• W1985940575 hasConceptScore W1985940575C2778382381 @default.
• W1985940575 hasConceptScore W1985940575C2778589496 @default.
• W1985940575 hasConceptScore W1985940575C2778961111 @default.
• W1985940575 hasConceptScore W1985940575C2779936836 @default.
• W1985940575 hasConceptScore W1985940575C2780930249 @default.
• W1985940575 hasConceptScore W1985940575C2910686401 @default.
• W1985940575 hasConceptScore W1985940575C42219234 @default.
• W1985940575 hasConceptScore W1985940575C71924100 @default.
• W1985940575 hasConceptScore W1985940575C77171857 @default.
• W1985940575 hasConceptScore W1985940575C89560881 @default.
• W1985940575 hasConceptScore W1985940575C98274493 @default.
• W1985940575 hasIssue "1" @default.
• W1985940575 hasLocation W19859405751 @default.
• W1985940575 hasLocation W19859405752 @default.
• W1985940575 hasOpenAccess W1985940575 @default.

• next