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• W1985963784 abstract "Hydrogen peroxide is a cell signaling agent that inactivates protein tyrosine phosphatases (PTPs) via oxidation of their catalytic cysteine residue. PTPs are inactivated rapidly during H(2)O(2)-mediated cellular signal transduction processes, but, paradoxically, hydrogen peroxide is a rather sluggish PTP inactivator in vitro. Here we present evidence that the biological buffer bicarbonate/CO(2) potentiates the ability of H(2)O(2) to inactivate PTPs. The results of biochemical experiments and high-resolution crystallographic analysis are consistent with a mechanism involving oxidation of the catalytic cysteine residue by peroxymonocarbonate generated via the reaction of H(2)O(2) with HCO(3)(-)/CO(2)." @default.
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• W1985963784 date "2011-09-19" @default.
• W1985963784 modified "2023-10-03" @default.
• W1985963784 title "The Biological Buffer Bicarbonate/CO₂ Potentiates H₂O₂-Mediated Inactivation of Protein Tyrosine Phosphatases" @default.
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• W1985963784 doi "https://doi.org/10.1021/ja2077137" @default.
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