Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985969166> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1985969166 endingPage "308" @default.
- W1985969166 startingPage "303" @default.
- W1985969166 abstract "The possibility of a retroviral etiology has long been raised in a number of autoimmune disorders. More recently, Sjögren's syndrome and rheumatoid arthritis were noted in transgenic mice carrying the tax gene of human T cell leukemia virus type I (HTLV-I). To evaluate the involvement of HTLV-I Tax in autoimmunity, its effect on expression of autoantigens was investigated. A metallothionein promoter-driven p40tax expression plasmid, pMAXRHneo-1, was stably transfected into Molt4 and Jurkat cells and the p40tax protein was induced with CdCl2. trans-Activation or trans-repression of autoantigens by HTLV-I Tax was studied by Western blot analysis utilizing autoantigen-specific murine monoclonal and rabbit polyvalent antibodies as well as sera from 161 autoimmune patients. Induction of p40tax of HTLV-I had no significant effect on levels of expression of common autoantigens Ul snRNP, Sm, Ro, La, HSP-70, topoisomerase I/Scl70, PCNA, and HRES-1. Expression of two potentially novel autoantigens, 44 and 46 kDa, was induced by p40tax as detected by sera of progressive systemic sclerosis patients, BAK and VAR. By contrast, expression of 24- and 34-kDa proteins was suppressed in response to induction of p40tax as detected by sera of systemic lupus erythematosus patients PUS and HOR. Because none of these patients were infected by HTLV-I, a protein functionally similar to p40tax may be involved in eliciting autoantigen expression and a subsequent autoantibody response in a minority of patients with PSS and SLE. Sera of autoimmune patients may also be utilized to detect novel proteins trans-activated or trans-repressed by p40tax of HTLV-I." @default.
- W1985969166 created "2016-06-24" @default.
- W1985969166 creator A5025875593 @default.
- W1985969166 creator A5035156230 @default.
- W1985969166 creator A5052080448 @default.
- W1985969166 creator A5058468600 @default.
- W1985969166 date "1994-03-01" @default.
- W1985969166 modified "2023-09-27" @default.
- W1985969166 title "Effect of p40taxtrans-Activator of Human T Cell Lymphotropic Virus Type I on Expression of Autoantigens" @default.
- W1985969166 cites W1481259039 @default.
- W1985969166 cites W1498843485 @default.
- W1985969166 cites W1529699918 @default.
- W1985969166 cites W1541258859 @default.
- W1985969166 cites W155539018 @default.
- W1985969166 cites W1570302970 @default.
- W1985969166 cites W1958996074 @default.
- W1985969166 cites W1971540091 @default.
- W1985969166 cites W1982566761 @default.
- W1985969166 cites W1993686365 @default.
- W1985969166 cites W1996631006 @default.
- W1985969166 cites W1997575391 @default.
- W1985969166 cites W2001042096 @default.
- W1985969166 cites W2003275596 @default.
- W1985969166 cites W2004337610 @default.
- W1985969166 cites W2022421315 @default.
- W1985969166 cites W2023517807 @default.
- W1985969166 cites W2023525914 @default.
- W1985969166 cites W2026509111 @default.
- W1985969166 cites W2028368276 @default.
- W1985969166 cites W2030372916 @default.
- W1985969166 cites W2031205383 @default.
- W1985969166 cites W2033411989 @default.
- W1985969166 cites W2034841844 @default.
- W1985969166 cites W2040000960 @default.
- W1985969166 cites W2044578185 @default.
- W1985969166 cites W2046572926 @default.
- W1985969166 cites W2053876438 @default.
- W1985969166 cites W2054391444 @default.
- W1985969166 cites W2055364212 @default.
- W1985969166 cites W2059862913 @default.
- W1985969166 cites W2061527579 @default.
- W1985969166 cites W2068516431 @default.
- W1985969166 cites W2069667541 @default.
- W1985969166 cites W2085236534 @default.
- W1985969166 cites W2086143621 @default.
- W1985969166 cites W2088265132 @default.
- W1985969166 cites W2100837269 @default.
- W1985969166 cites W2128635872 @default.
- W1985969166 cites W63931606 @default.
- W1985969166 doi "https://doi.org/10.1089/aid.1994.10.303" @default.
- W1985969166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8018391" @default.
- W1985969166 hasPublicationYear "1994" @default.
- W1985969166 type Work @default.
- W1985969166 sameAs 1985969166 @default.
- W1985969166 citedByCount "4" @default.
- W1985969166 crossrefType "journal-article" @default.
- W1985969166 hasAuthorship W1985969166A5025875593 @default.
- W1985969166 hasAuthorship W1985969166A5035156230 @default.
- W1985969166 hasAuthorship W1985969166A5052080448 @default.
- W1985969166 hasAuthorship W1985969166A5058468600 @default.
- W1985969166 hasConcept C153911025 @default.
- W1985969166 hasConcept C159047783 @default.
- W1985969166 hasConcept C159654299 @default.
- W1985969166 hasConcept C163764329 @default.
- W1985969166 hasConcept C203014093 @default.
- W1985969166 hasConcept C2522874641 @default.
- W1985969166 hasConcept C2780130043 @default.
- W1985969166 hasConcept C86803240 @default.
- W1985969166 hasConceptScore W1985969166C153911025 @default.
- W1985969166 hasConceptScore W1985969166C159047783 @default.
- W1985969166 hasConceptScore W1985969166C159654299 @default.
- W1985969166 hasConceptScore W1985969166C163764329 @default.
- W1985969166 hasConceptScore W1985969166C203014093 @default.
- W1985969166 hasConceptScore W1985969166C2522874641 @default.
- W1985969166 hasConceptScore W1985969166C2780130043 @default.
- W1985969166 hasConceptScore W1985969166C86803240 @default.
- W1985969166 hasIssue "3" @default.
- W1985969166 hasLocation W19859691661 @default.
- W1985969166 hasLocation W19859691662 @default.
- W1985969166 hasOpenAccess W1985969166 @default.
- W1985969166 hasPrimaryLocation W19859691661 @default.
- W1985969166 hasRelatedWork W1996464156 @default.
- W1985969166 hasRelatedWork W2017482091 @default.
- W1985969166 hasRelatedWork W2058737939 @default.
- W1985969166 hasRelatedWork W2101875571 @default.
- W1985969166 hasRelatedWork W2139983200 @default.
- W1985969166 hasRelatedWork W2146466204 @default.
- W1985969166 hasRelatedWork W2469794603 @default.
- W1985969166 hasRelatedWork W2907025905 @default.
- W1985969166 hasRelatedWork W4221024504 @default.
- W1985969166 hasRelatedWork W1564372652 @default.
- W1985969166 hasVolume "10" @default.
- W1985969166 isParatext "false" @default.
- W1985969166 isRetracted "false" @default.
- W1985969166 magId "1985969166" @default.
- W1985969166 workType "article" @default.