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• W1985975649 abstract "No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Apr 2000EFFECTS OF AN ENVIRONMENTAL ANTI-ANDROGEN ON ERECTILE FUNCTION IN AN ANIMAL PENILE ERECTION MODEL SUSAN E. BRIEN, JEREMY P.W. HEATON, WILLIAM J. RACZ, and MICHAEL A. ADAMS SUSAN E. BRIENSUSAN E. BRIEN More articles by this author , JEREMY P.W. HEATONJEREMY P.W. HEATON More articles by this author , WILLIAM J. RACZWILLIAM J. RACZ More articles by this author , and MICHAEL A. ADAMSMICHAEL A. ADAMS More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)67770-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Erectile function is testosterone dependent. For example, interference with either the levels or receptor binding of this steroid hormone may induce erectile dysfunction. Several environmental contaminants can interfere with the actions of endogenous hormones and have been termed ‘endocrine disrupters.’p,p-DDE, a prominent and persistent metabolite of the insecticide DDT, has been shown to be an androgen receptor antagonist. The objective was to determine whether endocrine disrupters, as exemplified by p,p-DDE, are factors in the etiology of erectile dysfunction. Materials and Methods: Using the established rat model of apomorphine-induced (80 μg./kg, s.c.) erections we assessed the dose-response effects of p,p-DDE in comparison to the known androgen receptor antagonist flutamide in acute (0.5 to 12 hours) and short-term (up to 8 weeks) experiments in both intact (Study 1) and castrated (Study 2) rats. As a follow up (Study 3), castrated rats treated with p,p-DDE were given increasing doses of testosterone (0.48 to 2.4 mg./kg., i.p.), eight weeks after p,p-DDE administration, to assess reversibility of p,p-DDE effect. Results: A single dose of flutamide (50 mg./kg., i.p.) was found to significantly decrease apomorphine-induced erections to less than 50% over 12 hours following flutamide administration with recovery of erectile response within 48 hours. In comparison, a single dose of p,p-DDE (500 mg./kg., i.p.) decreased apomorphine-induced erections for at least two weeks (1.15 ± 0.3 versus 2.5 ± 1.1). Castration significantly decreased apomorphine-induced erections to approximately 0.5 erections/30 minutes. Flutamide (50 mg./kg.; i.p.) or p,p-DDE (50 mg./kg.; i.p.) did not further suppress the apomorphine erections in castrated rats. Testosterone supplementation (480 μg./kg; s.c.) in vehicle treated castrated rats recovered erectile response to pre-castrated levels, whereas p,p-DDE treated castrated rats required 4 times the dose of testosterone (2 mg./kg.; s.c.) given to vehicle treated rats to recover erections. Conclusions: The endocrine disrupter p,p-DDE can markedly interfere with erectile function and demonstrates persistence after a single dose. This supports our novel concept that environmental hormones may cause erectile dysfunction. References 1 : Impotence and its medical and psychosocial correlates: results of the Massachusetts male aging study. J Urol1994; 151: 54. Abstract, Google Scholar 2 : Evidence for decreasing quality of semen during past 50 years. Br Med J1992; 305: 609. Google Scholar 3 : Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida. Environ Health Perspect1994; 102: 680. Google Scholar 4 : Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect1993; 101: 378. Google Scholar 5 : Our Stolen Future. Boston: Little Brown1996. 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Google Scholar From the Departments of Pharmacology & Toxicology and Urology, Queen’s University, and the Human Sexuality Group, Kingston General Hospital, Kingston, Ontario, Canada© 2000 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 163Issue 4April 2000Page: 1315-1321 Advertisement Copyright & Permissions© 2000 by American Urological Association, Inc.Keywordsenvironmental hormoneserectile dysfunctionendocrine disruptersimpotenceMetricsAuthor Information SUSAN E. BRIEN More articles by this author JEREMY P.W. HEATON More articles by this author WILLIAM J. RACZ More articles by this author MICHAEL A. ADAMS More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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