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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985976602> ?p ?o ?g. }

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• W1985976602 abstract "The estrogen receptors (ERs) α and β possess a constitutive N-terminal activation function (AF-1) whose activity can be modulated by kinase signaling pathways. We demonstrate here that phosphorylation of AF-1 by MAP kinase (MAPK) leads to the recruitment of steroid receptor coactivator-1 (SRC-1) by ERβ in vitro. Enhancement of the interaction between SRC-1 and ERβ AF-1 is also observed in vivo in cells either treated with EGF or expressing activated Ras. Two serine residues in ERβ AF-1, of which one is contained within a motif present in other steroid receptors, are critical for physical interaction with SRC-1 and transcriptional activation. Our results establish a role for nuclear receptor phosphorylation in the recruitment of SRC-1 and provide a molecular basis for ligand-independent activation by ERβ via the MAPK pathway." @default.
• W1985976602 created "2016-06-24" @default.
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• W1985976602 date "1999-04-01" @default.
• W1985976602 modified "2023-10-13" @default.
• W1985976602 title "Ligand-Independent Recruitment of SRC-1 to Estrogen Receptor β through Phosphorylation of Activation Function AF-1" @default.
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• W1985976602 doi "https://doi.org/10.1016/s1097-2765(00)80479-7" @default.
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